Abstract: SA-PO945
The Significance of Mini-PET and Fibrosis-Related Factors in Effluents in Peritoneal Function
Session Information
- Peritoneal Dialysis: Inflammation, Peritoneal Transport
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 703 Dialysis: Peritoneal Dialysis
Authors
- Horikoshi, Keisuke, Kanazawa University, Kanazawa, Japan
- Sakai, Norihiko, Kanazawa University, Kanazawa, Japan
- Ogura, Hisayuki, Kanazawa University, Kanazawa, Japan
- Sato, Koichi, Kanazawa University, Kanazawa, Japan
- Miyagawa, Taro, Kanazawa University, Kanazawa, Japan
- Yamauchi, Hiroyuki, Kanazawa University, Kanazawa, Japan
- Kitajima, Shinji, Kanazawa University, Kanazawa, Japan
- Toyama, Tadashi, Kanazawa University, Kanazawa, Japan
- Hara, Akinori, Kanazawa University, Kanazawa, Japan
- Iwata, Yasunori, Kanazawa University, Kanazawa, Japan
- Shimizu, Miho, Kanazawa University, Kanazawa, Japan
- Oota, Satoshi, Toyama City Hospital, Toyama, Japan
- Ishida, Yoichi, Toyama City Hospital, Toyama, Japan
- Wada, Takashi, Kanazawa University, Kanazawa, Japan
Background
Peritoneal dysfunction characterized by peritoneal fibrosis is the problem of long-term peritoneal dialysis. Recent studies have reported that sodium sieving (ΔNa) in mini-PET has the correlation with free water transport (FWT) and peritoneal fibrosis. We previously reported that lysophosphatidic acid (LPA) signaling-dependent connective tissue growth factor (CTGF) was significant to peritoneal fibrosis. Therefore, we examined the association of mini-PET markers with fibrosis-related factors in effluents.
Methods
We performed mini-PET (1hr-dwell) for 43 patients (60 samples) and assessed peritoneal function-related factors such as ΔNa and FWT. ΔNa was determined by the difference of sodium concentration in dialysate between 1hr and 0hr, and FWT by ultrafiltration volume except for the influence of sodium removal. In addition, we measured autotaxin (ATX), which is the enzyme of LPA production pathway, and CTGF concentrations as the fibrosis-related factors. We also performed standard-PET (4hrs-dwell) to assess D/P Cr and D/D0, and estimated the association of these values with mini-PET markers as well as the fibrosis-related factors.
Results
ΔNa had the correlation with FWT (r=0.86, p<0.01), D/P Cr (r=-0.28, p<0.05), D/D0 (r=0.40, p<0.01). In cases observed over the years (n=16), ΔNa at 1st year had the correlation with FWT (r=0.82, p<0.01) and D/P Cr (r=-0.65, p<0.01) at 2nd year. The changes of ΔNa had the correlation with the change of ultrafiltration (r=0.61, p<0.05). Moreover, ΔNa had the correlation with ATX (r=-0.80, p<0.01) and CTGF (r=-0.75, p<0.01).
Conclusion
ΔNa and fibrosis-related factors in effluents have the possibility to be the predictive factors of peritoneal function.