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Abstract: TH-PO639

Relationship Between Plasma Concentration of Adiponectin and Kidney Function in the Elderly Subjects: Results of the PolSenior Study

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Adamczak, Marcin, Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland
  • Dudzicz, Sylwia Malgorzata, Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland
  • Chudek, Jerzy, Medical University of Silesia, Katowice, Poland
  • Zejda, Jan E., Medical University of Silesia, Katowice, Poland
  • Grodzicki, Tomasz, Jagiellonian University Medical College, Krakow, Poland
  • Wiecek, Andrzej, Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland
Background

Adiponectin is an adipose tissue hormone involved in the regulation of glucose metabolism and fatty acid breakdown. Based on meta-analyzes, it was documented that higher plasma adiponectin concentrations in CKD patients are associated with lower risk of cardiovascular complications. As adiponectin is mostly metabolized in the kidneys it is important to establish the relationship between glomerular filtration rate (GFR) and adiponectinemia. The aim of this study was to assess the plasma concentration of adiponectin in relation to GFR in the older population-based PolSenior study cohort.

Methods

The PolSenior study was a multicenter study which assessed the health and socio-economic status of older adults in Poland. In 3913 subjects aged 65 years or above (2041 male and 1872 female, BMI 28.1±5.1 kg/m2, mean age 79±9 years) plasma adiponectin concentration (ELISA; B-Bridge International) were measured. GFR was estimated using a short MDRD formula. The results are presented as means with standard deviations.

Results

In studied subjects eGFR was 76 ml/min/1.73 m2. eGFR below 60 ml/min/1.73 m2 was observed in 842 (22%) subjects. Plasma concentration of adiponectin was 11.9±6.4 µg/ml. In subjects with eGFR < 60 ml/min/1.73 m2 significantly higher plasma adiponectin concentrations were observed compared to subjects with eGFR ≥ 60 ml/min/1.73 m2 (12.5±6.7 vs. 11.8±6.3, p=0.01). In the elderly subjects plasma adiponectin concentration depends strongly on BMI (R= -0.28; p<0.001) and marginally on the kidney function (R=-0.05; p=0.005). Multivariate regression analysis including plasma adiponectin concentration, BMI, eGFR, occurrence of diabetes and hypertension, showed that BMI and prevalence of diabetes (b=-0.24, p<0.001, b=-0.11, p<0.0001, respectively) but not eGFR explain variability of plasma adiponectin concentration.

Conclusion

In the older subjects from general population plasma adiponectin is weakly affected by kidney function.