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Kidney Week

Abstract: FR-PO263

Association of Arterial Stiffness with Kidney Function Among Adults Without CKD

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention


  • Itano, Seiji, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Yano, Yuichiro, Duke University, Durham, North Carolina, United States
  • Kanegae, Hiroshi, Genkiplaza Medical Center For Health Care, Kudanminami, Chiyoda-ku, Tokyo, Japan
  • Nagasu, Hajime, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Kobayashi, Yusuke, YCU Center for Novel and Exploratory Clinical Trials (Y-NEXT), Yokohama, Japan
  • Makino, Hirofumi, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, OKAYAMA, Japan
  • Townsend, Raymond R., University of Pennsylvania School of Medicine, Villanova, Pennsylvania, United States
  • Budoff, Matthew Jay, UCLA School of Medicine, Torrance, California, United States
  • Bakris, George L., The University of Chicago Medicine, Chicago, Illinois, United States
  • Kashihara, Naoki, Kawasaki Medical School, Kurashiki, Okayama, Japan

Associations of aortic stiffness with chronic kidney disease (CKD), including albuminuria and low estimated glomerular filtration rate (eGFR) have been reported in CKD patients. However, it is unclear that whether arterial stiffness is associated with an increased risk for kidney dysfunction among persons without CKD, and whether the association differs by sex.


We analyzed data from the national health check-up system in Japan, which enrolled persons who completed assessments of cardio-ankle vascular index (CAVI) and kidney function in 2005 and 2015. CAVI is a measure of arterial stiffness based on stiffness parameter β. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or eGFR <60 mL/min per 1.73 m2. The primary outcome was incident CKD events. Cox proportional hazards models were used to assess the associations between CAVI measurements, assessed as the highest versus lower quartile groups (CAVI measurements≧8.1 versus <8.1), and subsequent CKD events.


The mean (±standard deviation) age of the 24,297 included participants was 46±13 years and 56% were female. Over a mean follow-up of 3.1 years, 1,435 CKD events occurred. In a multivariable analysis, the highest versus lower quartile of CAVI measurements was associated with an increased risk for CKD events (hazard ratio [HR], 1.3; 95% confidence interval [CI], 1.1, 1.5) with interaction by sex (p <0.001). Adjusted HR (95% CI) for CKD events was 1.5 (95% CI, 1.2, 1.9) in men and 1.1 (95% CI, 0.95, 1.4) in women for the highest versus lower quartile of CAVI measurements.


CAVI measurements ≧8.1 versus <8.1 was associated with an increased risk for CKD events, and the association was stronger in men than in women. CAVI measurements may help identify persons at higher risk for CKD events.


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