Kidney Week

Abstract: FR-PO263

Association of Arterial Stiffness with Kidney Function Among Adults Without CKD

Session Information

• CKD: Epidemiology and Risk Factors
  November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Itano, Seiji, Kawasaki Medical School, Kurashiki, Okayama, Japan

Seiji Itano,



• Yano, Yuichiro, Duke University, Durham, North Carolina, United States

Yuichiro Yano,



• Kanegae, Hiroshi, Genkiplaza Medical Center For Health Care, Kudanminami, Chiyoda-ku, Tokyo, Japan

Hiroshi Kanegae,



• Nagasu, Hajime, Kawasaki Medical School, Kurashiki, Okayama, Japan

Hajime Nagasu,



• Kobayashi, Yusuke, YCU Center for Novel and Exploratory Clinical Trials (Y-NEXT), Yokohama, Japan

Yusuke Kobayashi,



• Makino, Hirofumi, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, OKAYAMA, Japan

Hirofumi Makino,



• Townsend, Raymond R., University of Pennsylvania School of Medicine, Villanova, Pennsylvania, United States

Raymond R. Townsend,



• Budoff, Matthew Jay, UCLA School of Medicine, Torrance, California, United States

Matthew Jay Budoff,



• Bakris, George L., The University of Chicago Medicine, Chicago, Illinois, United States

George L. Bakris,



• Kashihara, Naoki, Kawasaki Medical School, Kurashiki, Okayama, Japan

Naoki Kashihara,

Background

Associations of aortic stiffness with chronic kidney disease (CKD), including albuminuria and low estimated glomerular filtration rate (eGFR) have been reported in CKD patients. However, it is unclear that whether arterial stiffness is associated with an increased risk for kidney dysfunction among persons without CKD, and whether the association differs by sex.

Methods

We analyzed data from the national health check-up system in Japan, which enrolled persons who completed assessments of cardio-ankle vascular index (CAVI) and kidney function in 2005 and 2015. CAVI is a measure of arterial stiffness based on stiffness parameter β. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or eGFR <60 mL/min per 1.73 m². The primary outcome was incident CKD events. Cox proportional hazards models were used to assess the associations between CAVI measurements, assessed as the highest versus lower quartile groups (CAVI measurements≧8.1 versus <8.1), and subsequent CKD events.

Results

The mean (±standard deviation) age of the 24,297 included participants was 46±13 years and 56% were female. Over a mean follow-up of 3.1 years, 1,435 CKD events occurred. In a multivariable analysis, the highest versus lower quartile of CAVI measurements was associated with an increased risk for CKD events (hazard ratio [HR], 1.3; 95% confidence interval [CI], 1.1, 1.5) with interaction by sex (p <0.001). Adjusted HR (95% CI) for CKD events was 1.5 (95% CI, 1.2, 1.9) in men and 1.1 (95% CI, 0.95, 1.4) in women for the highest versus lower quartile of CAVI measurements.

Conclusion

CAVI measurements ≧8.1 versus <8.1 was associated with an increased risk for CKD events, and the association was stronger in men than in women. CAVI measurements may help identify persons at higher risk for CKD events.

Funding

• Private Foundation Support