Abstract: SA-PO833
Dietary Zinc Amount Is Associated with Incident CKD in General Population
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1300 Health Maintenance, Nutrition, and Metabolism
Authors
- Han, Dae-Suk, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Jo, Wonji, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Kim, Hyung Woo, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Joo, Youngu su, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Nam, Ki heon, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Park, Jung Tak, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
Background
Previous study suggests that zinc is associated with diabetes. No studies have undergone the association of incident chronic renal disease (CKD) and zinc consumption amount in a preserved renal function population. Data from the Korean Genome and Epidemiology Study, a prospective community-based cohort study were used to assess the between zinc consumption amount and incident CKD.
Methods
Zinc consumption amount was calculated by a 24-h dietary recall Food Frequency Questionnaire and converted into relative zinc consumption amount with energy-adjust method. A. total 7821 participants were analyzed with a primary of incident CKD that defined as estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2.
Results
The mean age was 52.1 ± 8.8 years, 47.5% were male, and mean eGFR was eGFR was 92.1 ± 16.1 ml/min/1.73m2. The mean daily zinc consumption amount was 8.6 ± 3.4 mg. During a median follow up of 11.5 (1.6 – 13.0) years and 71417 person-year observation, CKD developed in 1428 (18.3%) participants. When the participants were categorized into quartiles according to energy-adjusted zinc intake, the lowest quartile was significantly associated with the development of incident CKD compared to third lowest quartile group in multivariable cox hazard analysis (Hazard ratio; 1.19; 95% Confidence Interval 1.02 – 1.39; P = 0.027) and this finding was consistent after further adjustment. The U shaped hazard association was noted between zinc consumption and incident CKD in restricted cubic spline analysis.
Conclusion
Thus, low zinc consumption was associated with the increased risk for CKD.