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Kidney Week

Abstract: FR-PO288

Body-Weight Fluctuation Is Associated with Rapid Kidney Function Decline

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Han, Dae-Suk, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Ko, Byounghwi, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Kang, Shinchan, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Joo, Youngu su, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Nam, Ki heon, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Park, Jung Tak, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
Background

The association between body-weight fluctuation and renal outcomes is unclear. We aimed to evaluate the effects of body-weight fluctuation on the rate of renal function deterioration in a prospective cohort of individuals with normal renal function.

Methods

Data were obtained from the Korean Genome and Epidemiology Study (KoGES). Body-weight fluctuation was determined using average successive variability (ASV), which was defined as the average absolute body weight change using repeated measurements for all participants. The decline rate of estimated glomerular filtration rate (eGFR) over time was calculated using linear regression analysis of serial eGFR measurements for each patient. Rapid eGFR decline was defined an average decline in eGFR ≥3 ml/min/1.73 m2 per year.

Results

In total, 7075 participants were analyzed. During a median follow-up of 11.7 (5.2-12.7) years, rapid eGFR decline was observed in 964 (13.6%) participants. When the participants were categorized into tertiles according to ASV, rapid eGFR decline was more prevalent in the highest ASV tertile group than in the lowest ASV group. Analyses using multiple logistic regression models revealed that the risk of rapid eGFR decline was significantly increased in the highest ASV tertile group compared to the lowest group (odds ratio, 1.51; 95% confidence interval 1.22-1.87). When ASV was treated as a continuous variable, an 1 kg increase in ASV was associated a 22% increased risk of rapid eGFR decline.

Conclusion

Body-weight fluctuation was significantly associated with an increased risk of rapid renal function decline in participants with normal renal function