Abstract: FR-PO1170
Renal Transplant Complications in Patients with and Without Gout
Session Information
- Transplantation: Clinical - Post-Transplant Complications
November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Francis-Sedlak, Megan, Horizon Therapeutics plc, Lake Forest, Illinois, United States
- LaMoreaux, Brian, Horizon Therapeutics plc, Lake Forest, Illinois, United States
- Holt, Robert J., Horizon Therapeutics plc, Lake Forest, Illinois, United States
Background
Graft-related complications are among the most serious issues solid-organ transplant recipients and their healthcare teams face post-operatively. Gout is a known frequent co-morbidity in transplant patients. Whether renal transplant patients with gout suffer from higher rates of transplant-related complications, as compared to transplant patients without gout, has not been investigated. We analyzed a large US population database to determine the overall transplant complication rate in patients having a renal transplant with and without gout.
Methods
A retrospective review of Humana Research Database claims (2007-2017) was undertaken to identify kidney transplant patients with ≥6 months in plan before and after transplant. Diagnostic gout codes (ICD9/10) were used to categorize patients into gout and non-gout groups. Additionally patients were classified as having gout pre- or post-transplant based on first gout code occurrance. Transplant complications were determined using codes for complications of transplanted kidney, unspecified and other complications of kidney transplant, kidney transplant rejection, failure, and infection.
Results
The database contained 6085 patients with a kidney transplant and ≥6 months in plan both pre and post-transplant. Of these, 1504 patients had ≥1 gout codes (the first code occurred in 909 patients pre-transplant and 595 post-transplant), and 4581 patients never had a gout code. The renal transplant complication rate in the overall cohort was 36.0%. Patients with gout had a higher complication rate (40.4%) than those without gout (34.6%, OR: 1.28, 95%CI: 1.136–1.443, p<0.001). The higher complication rate in gout patients was driven by those who developed gout post-transplant.(Table 1)
Conclusion
Our analysis indicates that patients with gout, especially those with gout arising post-transplant, suffered from higher rates of overall transplant-related complications. In addition to more research on this topic, an increased focus on awareness and screening of renal transplant patients for gout is warranted.
Table 1. Renal transplant-related complications
| Group | Number of Patients | Number with Complications | % with Complications |
| Enrolled Patients | 6085 | 2191 | 36.0% |
| Gout and Transplant | 1504 | 607 | 40.4% |
| Gout Pre-Transplant | 909 | 304 | 33.4% |
| Gout Post-Transplant | 595 | 303 | 50.9% |
| No Gout | 4581 | 1584 | 34.6% |
Funding
- Commercial Support –