Abstract: FR-PO411
Hypomagnesemia with High FGF-23 Is a Significant Risk Factor for Cardiovascular Disease in Hemodialysis Patients
Session Information
- Hemodialysis and Frequent Dialysis - III
November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Author
- Tashiro, Manabu, Kawashima Hospital, City of Tokushima, 1-39 kitasako1banchou, Japan
Background
In patients with chronic kidney disease, cardiovascular disease is the major cause of mortality and morbidity. Magnesium has been shown to impact cardiovascular health positively. Most previous cohort studies and their meta-analysis have shown a link between high serum phosphate levels and high FGF23 levels and an increased cardiovascular risk. However, few studies have investigated parameters associated with magnesium levels in hemodialysis (HD) patients. Accordingly, we examined the clinical significance of magnesium (Mg) cross-sectionally, and investigated the relationship between Mg levels and FGF23 levels.
Methods
Eighty-nine HD patients were enrolled. Their mean age was 66.9 ± 11.3 years, and the mean duration of HD treatment was 10.9 ± 8.1 years. Twenty-six patients had diabetes mellitus (DM) and eighteen patients had cardiovascular diseases. We analyzed their medical history, echocardiography, computed tomography, biochemical measurements, cardiovascular morbidity, mortality, etc. We identified prospective studies reporting associations between Mg and FGF23 concentrations and parameters. Statistical significance of the difference between groups was determined by the chi-square test. All statistical analyses in this study were performed with SPSS statistics software 22 for Windows.
Results
The number of cardiovascular disease patients was significantly higher in the group with a serum Mg level of less than 2.5 mg/dl (P = 0.015) but was not correlated to serum Mg level. The serum FGF23 level was related to cardiovascular disease (P = 0.04). There was no relationship between cardiovascular disease and serum P level. Comparing high FGF23 to low FGF23, cardiovascular disease was significantly increased in the low Mg group (P = 0.021) but not in the high Mg group (P = 0.426). The odds ratio for cardiovascular disease in the high FGF23 group compared with the low FGF23 group was 3.38. The association between FGF23 and cardiovascular disease was modified significantly by Mg level.
Conclusion
We suggest that in cardiovascular disease, FGF23 and serum Mg levels are more influenced by the serum P level. High serum FGF23 was associated with cardiovascular disease in hemodialysis patients with low Mg level, but not in those with high Mg level. In particular, the combination of low Mg level and high FGF23 level is a risk factor for cardiovascular disease.