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Kidney Week

Abstract: FR-PO003

Epidemiology of Patients Receiving Continuous Renal Replacement Therapy: The Multicenter CRRTNet Study

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention


  • Rewa, Oleksa G., University of Alberta, Edmonton, Alberta, Canada
  • Heung, Michael, University of Michigan, Ann Arbor, Michigan, United States
  • House, Andrew A., LHSC University Hospital, London, Ontario, Canada
  • Monga, Divya, University of Mississippi Medical Center, Madison, Mississippi, United States
  • Neyra, Javier A., University of Kentucky Medical Center, Lexington, Kentucky, United States
  • Secic, Michelle, Secic Statistical Consulting, Inc., Cleveland, Ohio, United States
  • Piazza, Robin, Watermark Research Partners, Inc, Indianapolis, Indiana, United States
  • Goldstein, Stuart, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
  • Bagshaw, Sean M., University of Alberta, Edmonton, Alberta, Canada

There have been limited studies evaluating key performance metrics of patients undergoing continuous renal replacement therapy (CRRT). Our aim was to assess the case-mix, acuity, diagnosis, clinical course and outcomes of patients undergoing CRRT.


CRRTnet is an international multicenter data registry of adult patients undergoing CRRT to assess the variations in CRRT prescription and delivery across quality domains and to develop and benchmark CRRT specific key performance indicators. We evaluated the demographic criteria of adult critically ill patients undergoing CRRT for greater than 24 hours. Data was analyzed descriptively.


In total, 1116 patients treated with CRRT were included in the registry. The mean (SD) age 57.9 (14.2) years, 58.5% were male, mean (SD) APACHE II and SOFA score were 28.8 (7.3) and 13.8 (3.9), respectively, 81.2% of patients were mechanically ventilated and 83.0% required vasopressor support. The most common admission diagnosis was respiratory failure (20.1%), followed by sepsis (16.2%), cardiovascular emergency (14.3%) and acute liver failure (6.0%). Mean serum creatinine at ICU admission was 331.9 (256.7) umol/L. The most common triggers for CRRT initiation were volume overload (47.8%), oligo-anuria (27.5%) hyperkalemia (5.7%), metabolic acidosis (3.7%) and uremia (1.9%). 46.9% of patients survived the ICU stay and 43.6% survived to hospital discharge. 34.2% of patients had complete renal recovery, 19.5 % of patients had partial renal recovery while 46.4% had ongoing need for RRT. Mean ICU and hospital lengths of stay were 20.5 (26.2) and 43.2 (44.4) days, respectively.


In this large multi-centre prospective registry of critically ill patients treated with CRRT the most common etiology of AKI requiring CRRT was sepsis and the most common specific indication was volume overload.


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