Abstract: SA-PO700
Renal Oxalosis in Adult Patients: A Relatively Common Entity of Often Unclear Etiology
Session Information
- Pathology and Lab Medicine: Clinical
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pathology and Lab Medicine
- 1602 Pathology and Lab Medicine: Clinical
Authors
- Yang, Yihe, Northwell Health, Bayside, New York, United States
- Sharma, Purva D., Northwell Health, Bayside, New York, United States
- Nair, Vinay, Northwell Health, Bayside, New York, United States
- Jhaveri, Kenar D., Northwell Health, Bayside, New York, United States
- Malieckal, Deepa A., Northwell Health, Bayside, New York, United States
- Wanchoo, Rimda, Northwell Health, Bayside, New York, United States
- Rosenstock, Jordan L., Northwell Health, Bayside, New York, United States
- Bijol, Vanesa, Northwell Health, Bayside, New York, United States
Background
The prevalence, manifestation and outcome of secondary oxalate nephropathy have not been extensively studied.
Methods
Retrospectively reviewed kidney biopsy cases with oxalate deposition (7/1/2017-12/31/2018).
Results
The prevalence of oxalate deposition on a kidney biopsy was 4.07%(25/615). Prior to biopsy, oxalate was anticipated in only 1 case. The etiology of oxalosis was clarified retrospectively in 14 cases, most commonly due to GI surgery (n=10) and increased oxalate intake (n=4). In 11 cases, etiology remained unknown, although at least 3 cases were exposed to antibiotics associated with secondary oxalosis. There was no significant clinical/pathological or survival difference between known vs. unknown cause groups. Multivariate COX regression showed that Cr at the time of biopsy (HR1.79,95%CI 0.71-4.51), background histological chronicity change(HR1.82, 95%CI 0.70-4.72) and oxalate density (HR2.27,95%CI 0.49-10.55) are associated with ESRD and patient death(-2LogLikelihood: 20.15 to 16.99,forward selection).
Conclusion
Oxalate deposition is common but rarely anticipated biopsy finding. Nephrologists need to consider surgical history and other secondary causes of oxalosis as causes of AKI and CKD.