Kidney Week

Abstract: FR-PO271

Association Between Endogenous Sex Hormones and Kidney Function: Cross-Sectional Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Session Information

• CKD: Epidemiology and Risk Factors
  November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Madrigal, Jessica M., University of Illinois at Chicago, Chicago, Illinois, United States

Jessica M. Madrigal,

• Ricardo, Ana C., University of Illinois at Chicago, Chicago, Illinois, United States

Ana C. Ricardo,

• Turyk, Mary, University of Illinois at Chicago, Chicago, Illinois, United States

Mary Turyk,

• Sargis, Robert, University of Illinois at Chicago, Chicago, Illinois, United States

Robert Sargis,

• Freels, Sally, University of Illinois at Chicago, Chicago, Illinois, United States

Sally Freels,

• Lash, James P., University of Illinois at Chicago, Chicago, Illinois, United States

James P. Lash,

• Persky, Victoria, University of Illinois at Chicago, Chicago, Illinois, United States

Victoria Persky,

• Daviglus, Martha L., University of Illinois at Chicago, Chicago, Illinois, United States

Martha L. Daviglus,

Background

The prevalence of end-stage renal disease is higher in males than females, despite the higher prevalence of chronic kidney disease (CKD) among females, suggesting that men are at higher risk of CKD progression. Sex steroid hormones have been proposed as a potential mechanism for these disparities. Few studies have examined the associations between endogenous sex hormone and kidney function.

Methods

We evaluated the cross-sectional associations between serum levels of endogenous sex hormones (luteinizing hormone (LH), follicle stimulating hormone (FSH), sex-hormone binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), estradiol, and testosterone) and measures of kidney function among participants in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Persistent Organic Pollutants, Endogenous Hormones and Diabetes in Latinos Ancillary Study. The ancillary study inclusion criteria selected male and post-menopausal female participants with normal glucose or prediabetes at baseline. Sex-stratified survey-weighted linear regression models were used to examine if ranked quartile hormone concentrations were associated with estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR), after adjusting for age, ethnicity, body mass index, systolic blood pressure, and fasting blood glucose.

Results

The study included 1,854 participants (mean age 55 years, 33% post-menopausal female, 52% prediabetic, geometric mean UACR 7.8 mg/g, and mean eGFR 93 ml/min/1.73 m²). Among females, LH and FSH were inversely associated with eGFR (β for highest versus lowest LH quartile= -8.7, 95% CI -13.9, -3.5, p=0.001; β for highest versus lowest FSH quartile= -12.4, 95% CI -19.0, -5.7, p=0.0003). Among males, LH was inversely associated with eGFR (β for highest versus lowest LH quartile= -5.5, 95% CI -9.4, -1.5, p=0.01), and LH and FSH were positively associated with UACR.

Conclusion

In our diverse subsample of Hispanics/Latinos that did not have diabetes, we observed associations of LH and FSH with kidney function measurements, after adjustment for multiple CKD risk factors. Our findings suggest that these gonadotropins may play a role in CKD.

Funding

• Other NIH Support