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Abstract: TH-PO578

Poor Correlation of Static Markers of Bone Turnover at the Iliac Crest vs. Greater Trochanter in Autopsy Specimens

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical

Authors

  • Hughes-Austin, Jan M., University of California, San Diego, La Jolla, California, United States
  • Dwight, Kathryn Danielle, University of California, San Diego, La Jolla, California, United States
  • Ginsberg, Charles, University of California, San Diego, La Jolla, California, United States
  • Tipps, Ann M p, University of California, San Diego, La Jolla, California, United States
  • Salusky, Isidro B., Mattel Children's Hospital, Los Angeles, California, United States
  • Ix, Joachim H., University of California, San Diego, La Jolla, California, United States
Background

Iliac crest bone biopsies and histomorphometry are the gold standard in the diagnosis of abnormalities within the Chronic Kideny Disease - Mineral and Bone Disorder (CKD-MBD), yet fractures more frequently occur around the greater trochanter of the hip. We compared bone turnover markers between these 2 anatomical sites in autopsies.

Methods

We collected bone tissue samples from the ipsilateral iliac crest and greater trochanter in 10 deceased individuals undergoing autopsy at University of California, San Diego between March-August 2018. Because post-mortem osteoblasts last <48 hours, we used osteoclast surface relative to bone surface (Oc.S/BS), eroded surface relative to bone surface (ES/BS), and osteoid volume relative to bone volume (OV/BV) as markers of bone turnover. We evaluated the correlation of these markers between the iliac crest and greater trochanter using Pearson correlations.

Results

Average age of these individuals was 57±16, 30% were women, and average time from death to autopsy was 3±2 days. We found that the Pearson correlation of Oc.S/BS at the iliac crest vs. greater trochanter was 0.44, p=0.37. Similarly, Pearson correlation of ES/BS and OV/BV were 0.30, p=0.44, and 0.003, p=0.99, respectively.

Conclusion

We found poor agreement of static measures of bone turnover between the iliac crest and greater trochanter. These data suggest that bone histomorphometric measures of the iliac crest may not provide reliable information about bone turnover at other anatomic sites.

Funding

  • NIDDK Support