Kidney Week

Abstract: FR-OR108

Peritoneal Dialysis (PD) Modality and Interference in Daily Life: Results from the PDOPPS

Session Information

• Peritoneal Dialysis: Innovations and Clinical Practice
  November 08, 2019 | Location: 147, Walter E. Washington Convention Center
  Abstract Time: 05:54 PM - 06:06 PM

Category: Dialysis

• 703 Dialysis: Peritoneal Dialysis

Authors

• Moraes, Thyago Proença de, Pontificia Universidade Catolica do Parana, Curitiba, Brazil

Thyago Proença de Moraes, MD, PhD



Thyago Proença de Moraes is currently Assistant Professor of Medicine and head of Nephrology at Pontificia Universidade Católica do Paraná, Curitiba, Brazil; Co-Chair of the Adequacy and Ultrafiltration workgroup of the PDDOPPS; Coordinator of the Brazilian Peritoneal Dialysis Multicenter Study (BRAZPD); coordinator of the Latin American Chapter of the ISPD; and Co-chair of the PD committee of the SLANH (Latin American Society of Nephrology and Hypertension) . In 2010, he was awarded with a motion of public recognition for services rendered on behalf of the population in the prevention and treatment of kidney disease by the Legislative Assembly of the State of Paraná. In 2012 and 2018, he was granted with a Young Investigator Award at the 14th and 17th Congress of the ISPD. He is a member of the editorial board of Peritoneal Dialysis International and Brazilian Journal of Nephrology.

• Zhao, Junhui, Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Junhui Zhao,

• Fuller, Douglas S., Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Douglas S. Fuller,

• McCullough, Keith, Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Keith McCullough,

• Bieber, Brian, Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Brian Bieber,

• Robinson, Bruce M., Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Bruce M. Robinson,

• Pisoni, Ronald L., Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Ronald L. Pisoni,

• Davies, Simon J., University Hospital of North Midlands, Stoke-on-Trent, United Kingdom

Simon J. Davies,

• Perl, Jeffrey, St. Michael's Hospital, Toronto, Ontario, Canada

Jeffrey Perl,

Group or Team Name

• on behalf of PDOPPS Dialysis Prescription and Fluid Management working group

Background

Patient-reported outcomes (PROs), including quality of life and life participation activities, are important considerations for patients receiving peritoneal dialysis. The relative effects of automated (APD) vs. continuous ambulatory (CAPD) modalities on PROs remain controversial.

Methods

We analyzed cross-sectional clinical and patient-reported data from the PD Outcomes and Practice Patterns Study (PDOPPS; 2014-2017; Australia, Canada, Japan, New Zealand, UK, US). Patients rated dialysis interference with 9 aspects of daily life on a 7-point Likert scale. Linear and logistic regressions were used to estimate associations of PD modality with the interference item scores (mean and grouped as response levels 4-6 vs 0-3), KDQOL Mental Component Summary (MCS), Physical Component Summary (PCS) scores, and the 10-item CES-D depression screening scale (scale scores grouped as ≥10 vs <10), adjusted for demographic, comorbidity, and treatment variables.

Results

The analysis included 1800 APD and 892 CAPD patients. After adjustment, APD (v. CAPD) patients had 0.04 higher mean interference score (95% CI=-0.09, 0.18), 0.05 lower MCS (-1.19, 1.09), 0.73 lower PCS (-1.73, 0.26), and 1.17 (0.94, 1.45) higher odds of CES-D ≥10 vs <10. APD (v. CAPD) patients reported less interference with employment (adjusted OR=0.83, 95% CI=0.62-1.12) and total PD time (0.86, 0.68-1.08), and greater interference with intimacy (1.18, 0.96-1.46) and the lives of family/friends (1.36, 1.09-1.70).

Conclusion

Summary PROs were generally similar for APD and CAPD patients, potentially due to non-randomized modality choice. However, domain specific differences in interference scores were observed that may be informative for patients when choosing PD modality type. Across both modalities, PD appears to interfere for the majority in domains of travel and employment suggesting that these are important areas to reduce the overall interference of PD with life activities.

Funding

• Commercial Support –