Abstract: FR-PO1137
The Incidence of BK Viremia Among Recipients Who Received Kidney Transplants (KT) from Hepatitis C-Infected and Uninfected Donors
Session Information
- Transplantation: Clinical - Post-Transplant Complications
November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Yazawa, Masahiko, University of Tennessee Health Science Center, Memphis, United States
- Cseprekál, Orsolya, Semmelweis University, Budapest, Hungary
- Talwar, Manish, University of Tennessee Health Science Center, Memphis, Tennessee, United States
- Balaraman, Vasanthi, University of Tennessee Health Science Center, Memphis, Tennessee, United States
- Eason, James D., University of Tennessee Health Science Center, Memphis, Tennessee, United States
- Molnar, Miklos Zsolt, University of Tennessee Health Science Center, Memphis, Tennessee, United States
Group or Team Name
- METEOR (MEthodist Transplant EpidemiOlogy Research) Group
Background
Our previous data showed KT from hepatitis C virus(HCV) infected donor to non-infected recipients might be associated with higher incidence of BK viremia.
Methods
One hundred and ninety-two deceased KT recipients (74 HCV infected(D+/R-) and 55 HCV negative (D-/R-) donor) to HCV negative recipients were included. Outcome was defined as time to incidence BK viremia which 1)was detectable in blood specimen by PCR (BK viremia;n=21), 2)was greater than 10,000 copies/mL (high BK viremia;n=9). We performed time to event analysis from KT to 120 days after KT with unadjusted and thymoglobulin dose adjusted Cox regression model.
Results
The mean age at KT was 52±11 years old and 80% were African-American. Table shows the baseline characteristics of HCV D+/R- and D-/R- groups. The median number of the highest viral copies was tended to be 5-fold higher in HCV D+/R- group (median:19,632; interquartile range (IQR):2,329-303,823 copies/mL) than D-/R- group (median:4,356; IQR:2,931-15,219 copies/mL,p=0.45). Figure shows the probability of the (high) BK viremia over the follow-up time. Compared to D-/R-, HCV D+/R- group reported similar probability of BK viremia in unadjusted (Hazard Ratio(HR):1.32, 95% Confidence Interval(CI):0.54-3.19) and adjusted (HR:1.28, 95%CI:0.52-3.13) model, a trend for higher risk for high BK viremia unadjusted (HR:2.87, 95%CI:0.60-13.8) and adjusted (HR:2.68, 95% CI:0.56-12.9) Cox regression model.
Conclusion
HCV D+/R- KT was not associated with higher incidence of BK viremia and showed trend for higher incidence of BK viremia.
Figure 1