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Abstract: SA-PO706

Kidney Function and Histopathology in Patients Undergoing Nephrectomy

Session Information

Category: Pathology and Lab Medicine

  • 1602 Pathology and Lab Medicine: Clinical

Authors

  • Gupta, Shruti, BWH, Boston, Massachusetts, United States
  • Li, Ping, Chinese PLA General Hospital, Beijing, China
  • Sarvode Mothi, Suraj, Brigham and Women''s, Boston, Massachusetts, United States
  • Waikar, Sushrut S., Harvard Medical School, Boston, Massachusetts, United States
  • McMahon, Gearoid M., Brigham and Women's Hospital, Brookline, Massachusetts, United States
Background

Existing data on kidney histopathologic findings and estimated glomerular filtration rate (eGFR) are derived largely from studies from kidney donor nephrectomy specimens. Our objective was to use non-neoplastic tissue from nephrectomy specimens to examine the association between eGFR and the degree of glomerulosclerosis (GS), interstitial fibrosis/tubular atrophy (IF/TA), and arteriosclerosis (AS).

Methods

We reviewed non-neoplastic kidney pathology reports from patients who underwent nephrectomy between 1999 and 2018 (n=1,195). We used linear regression models to determine the association between the degree of GS, IFTA, and AS, with eGFR at the time of nephrectomy. We also assessed the relation between age and eGFR, stratifying by the degree of GS, IFTA, and AS.

Results

Greater %GS, IFTA, and AS were associated with lower eGFR (Figure 1). After MV-adjustment, eGFR was most strongly associated with greater degrees of IFTA [-29.0 ml/min/1.73m2 (95% CI -34.2, -24.0), p <0.001 among those with >50% vs <10% IFTA]. The slope of decline in eGFR within each category of GS, IFTA, AS, and chronicity score did not differ based on age (Figure 2) (interaction term p >0.05).

Conclusion

Independent of age, lower eGFR was associated with a greater severity of histopathologic changes.

Funding

  • NIDDK Support