Kidney Week

Abstract: SA-PO814

Skipping Breakfast and Dinner and Incidence of Proteinuria: A Retrospective Cohort Study

Session Information

• Health Maintenance, Nutrition, Metabolism - II
  November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1300 Health Maintenance, Nutrition, and Metabolism

Authors

• Tomi, Ryohei, Osaka University, Toyonaka, Japan

Ryohei Tomi,

• Yamamoto, Ryohei, Osaka University, Suita, Japan

Ryohei Yamamoto,

• Shinzawa, Maki, Osaka University, Suita, Japan

Maki Shinzawa,

• Yoshimura, Ryuichi, Osaka University Graduate School of Medicine, Suita, Japan

Ryuichi Yoshimura,

• Ozaki, Shingo, Osaka University, Suita, Japan

Shingo Ozaki,

• Fujii, Yoshiyuki, Osaka University, Suita, Japan

Yoshiyuki Fujii,

• Kimura, Yoshiki, National Hospital Organization Osaka National Hospital, Osaka, Japan

Yoshiki Kimura,

• Nakanishi, Kaori, Osaka University, Suita, Japan

Kaori Nakanishi,

• Taneike, Manabu, Osaka University, Suita, Japan

Manabu Taneike,

• Nishida, Makoto, Osaka University, Suita, Japan

Makoto Nishida,

• Kudo, Takashi, Osaka University, Suita, Japan

Takashi Kudo,

• Yamauchi-Takihara, Keiko, Osaka University, Health Care Center, Toyonaka, Japan

Keiko Yamauchi-Takihara,

• Aoki, Katsunori, Osaka University, Suita, Japan

Katsunori Aoki,

• Isaka, Yoshitaka, Osaka University Graduate School of Medicine, Suita, Japan

Yoshitaka Isaka,

• Moriyama, Toshiki, Osaka University, Health Care Center, Toyonaka, Japan

Toshiki Moriyama,

Background

Chronic kidney disease (CKD) caracterized by proteinuria and low glomerular filtration rate (GFR), is one of the major risk factors of end-stage kidney disease, cardiovascular disease (CVD), and mortality. Recent studies showed that skipping breakfast was associated with type 2 diabetes (T2D) and CVD. Regarding CKD, little information is available about a clinical impact of skipping breakfast on CKD. The aim of the present study was to assess an association between breakfast frequency and incidence of proteinuria in a retrospective cohort study, along with lunch and dinner frequency.

Methods

The present study included 7,881 employees of Osaka University, one of the largest national university in Japan, who underwent their annual health checkups between April 2004 and March 2013, and had nagative or trace result of dipstick urinary protein and estimated GFR (eGFR) ≧60 ml/min/1.73m² at their baseline visit. Main exposure of interest was self-reported frequency of breakfast, lunch and dinner at their baseline visit: almost every day vs. irregularly. The associations of irregular breakfast, lunch, and dinner with the incidence of proteinuria defined as 1+ or more of dipstick urinary protein, using a Cox proportional hazards model adjusting for clinically relevant factors.

Results

Baseline clinical characteristics of 7,881 employees: age, mean 35 ± SD 9 years; body mass index, 21.6 ± 3.2 kg/m²; eGFR 92 ± 15 ml/min/1.73m²; current treatment for hypertension and CVD, 6.5% and 0.2%, respectively. During median 4.8 (interquartile range 2.1-7.7) years of the observational period, 582 (13.2%) males and 446 (12.9%) females developed proteinuria. In females, irregular breakfast and dinner was significantly associated with the incidence of proteinuria in a multivariable-adjusted model, whereas not irregular lunch (adjusted incident rate ratio of irregular breakfast, lunch, and dinner: 1.49 [1.22-1.81], 1.21 [0.82-1.79], and 1.41 [1.01-1.97], respectively). In contrast, no association was observed in males (0.95 [0.75-1.21], 1.00 [0.69-1.46], and 0.88 [0.50-1.56]).

Conclusion

Skipping breakfast and dinner were risk factors of proteinuria in females, not males.