Abstract: SA-PO672
Predictors of Kidney Function Recovery in Glomerular Disease After Dialysis Initiation
Session Information
- Glomerular Diseases: ANCA, Anti-GBM, Kidney Biopsy
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1203 Glomerular Diseases: Clinical, Outcomes, and Trials
Authors
- Fallahzadeh Abarghouei, Mohammad Kazem, University of California San Francisco, San Francisco, California, United States
- Hsu, Raymond K., University of California San Francisco, San Francisco, California, United States
- Liu, Kathleen D., University of California San Francisco, San Francisco, California, United States
- Tuot, Delphine S., University of California San Francisco, San Francisco, California, United States
- McCulloch, Charles E., University of California San Francisco, San Francisco, California, United States
- Ku, Elaine, University of California San Francisco, San Francisco, California, United States
Background
Many patients with glomerulonephritis (GN) may require dialysis acutely, but the proportion of patients who recover kidney function has not been well-described. We examined characteristics of patients with GN who initiated outpatient dialysis and recovered sufficient function to become dialysis independent as well as trends in rates of recovery by GN type over time.
Methods
We performed a retrospective cohort study of adults ≥18 years who initiated outpatient dialysis between 1995-2015 and had a GN as cause of ESKD according to the USRDS. We defined recovery as a 60-day dialysis-free period and alive for at least 90 days after stopping dialysis within one year of dialysis initiation. We used adjusted Cox models to examine predictors of recovery.
Results
Of 173,348 patients, 4.6% recovered renal function and 13.3% died within one year after dialysis initiation. Recovery within the first 90 days of dialysis initiation was most likely among those with post-infectious GN or hemolytic uremic syndrome (HUS) [Figure]. Younger age, female gender, non-Hispanic white race, and having post-infectious, lupus and vasculitis as the cause of ESKD were associated with higher odds of recovery [Table].
Conclusion
Nearly one in four patients who initiated outpatient dialysis due to post-infectious and HUS diagnoses recovered kidney function within one year. Close follow-up after dialysis initiation is warranted.