Kidney Week

Abstract: FR-OR059

Impaired Sleep Quality Is Associated with Incident Albuminuria in Hispanics/Latinos: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Session Information

• Genes, Environment, and Lifestyle: Risk Factors for CKD
  November 08, 2019 | Location: Salon C, Walter E. Washington Convention Center
  Abstract Time: 06:06 PM - 06:18 PM

Category: CKD (Non-Dialysis)

• 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Ansari, Sajid Q., University of Illinois at Chicago, Chicago, Illinois, United States

Sajid Q. Ansari, MD



Sajid Ansari is a second year Nephrology fellow at University of Illinois at Chicago (UIC) currently pursuing a Master of Science in Clinical and Translational Science degree at the UIC School of Public Health. Sajid’s long-term goal is to become an independent investigator focused on studying racial/ethnic disparities in chronic kidney disease. Originally from the city of Hyderabad, India, Sajid lives in the suburbs of Chicago with his wife and three sons. He is a sports enthusiast with keen interest in soccer, table-tennis and cricket. Recently, he has found new interest in oriental perfume oils.

• Ricardo, Ana C., University of Illinois at Chicago, Chicago, Illinois, United States

Ana C. Ricardo,

• Chen, Jinsong, University of Illinois at Chicago, Chicago, Illinois, United States

Jinsong Chen,

• Zee, Phyllis C., Northwestern University, Chicago, Illinois, United States

Phyllis C. Zee,

• Rosas, Sylvia E., Joslin Diabetes Center, Boston, Massachusetts, United States

Sylvia E. Rosas,

• Talavera, Gregory A., San Diego State University, Chula Vista, California, United States

Gregory A. Talavera,

• Cespedes feliciano, Elizabeth M., Kaiser Permanente Northern California, Oakland, California, United States

Elizabeth M. Cespedes feliciano,

• Cai, Jianwen, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Jianwen Cai,

• Franceschini, Nora, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Nora Franceschini,

• Patel, Sanjay R., University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Sanjay R. Patel,

• Daviglus, Martha L., University of Illinois at Chicago, Chicago, Illinois, United States

Martha L. Daviglus,

• Lash, James P., University of Illinois at Chicago, Chicago, Illinois, United States

James P. Lash,

Background

Emerging evidence suggests that short duration and poor quality sleep may be associated with progression of chronic kidney disease (CKD). Little is known about the relationship of sleep duration/quality with incident albuminuria.

Methods

Analyses included data from 1662 U.S. Hispanic/Latino adults aged 18-64 years enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sueno Sleep Ancillary Study, who completed 7 days of wrist actigraphy (2011-2013) and a follow-up visit (2014-2017), and did not have CKD (estimated glomerular filtration rate [eGFR] ≥ 60 ml/min/1.73m² and urine albumin-to-creatinine ratio [ACR] <30 mg/g) at baseline. Incident albuminuria was defined as ACR ≥30 mg/g. Validated computer software algorithms were used to assess sleep duration and sleep fragmentation (calculated by summing the percentage of the sleep period that is spent moving and the percentage of the number of immobile phases that last 1minute or less). Poisson regression with follow-up years as an offset was used accounting for HCHS/SOL complex sampling design.

Results

At baseline, mean age was 37.5 years and 51.9% were female. In 5.7 years median follow-up, 71 individuals developed incident albuminuria. Higher sleep fragmentation was associated with higher incident rate of albuminuria after adjusting for center, age, sex, education, diabetes, systolic blood pressure, body mass index, cardiovascular disease, depression, eGFR, and ACR (Table). Sleep duration was not associated with new-onset albuminuria.

Conclusion

Among US Hispanic/Latinos, fragmented sleep was associated with new-onset albuminuria. These findings could have implications for preventive strategies in a population which experiences a high burden of CKD.

Funding

• NIDDK Support