Abstract: SA-PO560
Modifiable Factors Associated with Health-Related Quality of Life in Patients with Diabetic Kidney Disease
Session Information
- Diabetic Kidney Disease: Pathology, Epidemiology
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 602 Diabetic Kidney Disease: Clinical
Authors
- Kim, Suhyun, samsung medical center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
- Park, Mee yeon, samsung medical center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
- Boo, Hyo jin, samsung medical center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
- Jang, Hye Ryoun, samsung medical center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
- Huh, Wooseong, samsung medical center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
- Kim, Yoon-Goo, samsung medical center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
- Kim, Dae joong, samsung medical center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
- Lee, Jung eun, samsung medical center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
Background
Poor health-related quality of life (HRQOL) is associated with increased cardiovascular risk and mortality in patients with kidney disease. Therefore, it is critical to identify potentially modifiable clinical factors contributing to poor HRQOL. This study examined clinical factors associated with poor HRQOL in patients with diabetic kidney disease (DKD) focusing on depression, anxiety, sleep quality, and physical activity.
Methods
Between April 2017 and March 2018, 141 adults (aged ≥18 years) with DKD were recruited in single tertiary hospital. HRQOL was assessed at baseline with the Short Form 36 (SF – 36) Health Survey Questionnaire. Poor HRQOL was defined as baseline scores blow the median value. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS). Sleep quality and physical activity were measured using Korean version of the Pittsburgh Sleep Quality Index (PSQI-K) and Short form of Global Physical Activity Questionnaire (GPAQ) respectively.
Results
The age was 65 [57-72] years old, and 73% (n=103) of participants were men. Prevalence of anxiety and depression were 17% (n=24) and 7% (n=10) respectively. Forty-eight (34%) subjects corresponded to poor sleepers and 40 (28%) subjects showed low physical activity. SF-36 scores were decreased with advanced CKD stages (stage 3, 79 [71-82]; stage 4, 71 [56-82]; stage 5, 70 [57-82]; p = 0.029 for trend). Anxiety, depression, and poor sleep quality were negatively correlated with SF-36 scores (p < 0.05). eGFR and physical activity were positively correlated with HRQOL scores (p < 0.05). In multivariable logistic analysis, depression scores were associated with poor HRQOL independently of age, sex, comorbidity, eGFR, anemia, sleep quality, anxiety and physical activity (odds ratio per 1-score increment, 1.51; 95% CI, 1.27-1.80, p < 0.001).
Conclusion
In patients with DKD, depression was a major determinant of poor HRQOL among the modifiable clinical factors such as anxiety, sleep and physical activity. Active surveillance of depression and psychosocial intervention should be considered to improve the well-being of these patients.