Abstract: FR-PO341
Establishment of a Virtual Slide System Linking to the Japan Renal Biopsy Registry
Session Information
- CKD: Clinical, Outcomes, Trials - II
November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Kaseda, Ryohei, Niigata University, Chuo-ku, Niigata, Japan
- Maruyama, Shoichi, Nagoya University Graduate School of Medicine, Nagoya, Japan
- Sugiyama, Hitoshi, Okayama University Graduate School, Okayama, Japan
- Shimizu, Akira, Nippion Medical School, Tokyo, Japan
- Yokoyama, Hitoshi, Kanazawa Medical University, Ishikawa, Japan
- Sato, Hiroshi, Clinical Pharmacology and Therapeutics, Graduate School of pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
- Narita, Ichiei, Niigata University, Chuo-ku, Niigata, Japan
Background
A virtual slide is a high-resolution digital image created from scanning specimens on glass slides. Digital images are saved in a storage system and viewed on a computer screen using slide viewing software that is accessed via a web browser. These images can be assessed in the same way as with microscopy. The Japan Renal Biopsy Registry (J-RBR) has been operated since 2007 by the Japanese Society of Nephrology’s Kidney Disease Registry Committee. As of December 2018, 143 facilities have joined the registry and data have been registered for more than 40,000 patients who underwent renal biopsy. The J-RBR is now one of the largest national registries in Japan and provides a wealth of information for examining actual conditions, conducting secondary research, and developing clinical practice guidelines.
We attempted to establish a virtual slide system of renal biopsy specimens that is linked to the J-RBR in order to increase the registry’s utility.
Methods
Installation of a server computer was made possible by a Grant-in-Aid for Intractable Renal Diseases Research, Research on Rare and Intractable Diseases, Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan. The server computer was constructed at Niigata University, image view software was installed (Aperio eSlide Manager®, Leica Microsystems K.K.), and the server was connected to the J-RBR server. When logged into their J-RBR accounts, users can access the J-RBR server to view the histopathology images via a web browser.
Results
The virtual slide system was linked to the J-RBR in March 2019, and virtual slides from more than 100 patients were registered during the first 2 months of operation. The digital images are available to all researchers with a J-RBR account.
Conclusion
The virtual slide system enables renal biopsy specimens to be viewed and diagnoses made via teleconsultations, and it can help pathologists establish a clinical consensus for diagnosis. The system should also increase the reliability of J-RBR data, which in turn will promote more secondary research, including machine learning, to be undertaken and provide precise information for guideline development.
Funding
- Government Support - Non-U.S.