Abstract: SA-PO712
Vasculopathy Plays an Essential Role During the Development and Relapse of Encapsulating Peritoneal Sclerosis in Conventional PD Solutions
Session Information
- Pathology and Lab Medicine: Clinical
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pathology and Lab Medicine
- 1602 Pathology and Lab Medicine: Clinical
Authors
- Tawada, Mitsuhiro, Koujyukai Kasugai Hospital, Kasugai, Japan
- Ito, Yasuhiko, Aichi Medical University, Nagakute, Aichi, Japan
- Sun, Ting, Nagoya University Graduate School of Medicine, Nagoya, Japan
- Suzuki, Yasuhiro, Nagoya University Graduate School of Medicine, Nagoya, Japan
- Mizuno, Masashi, Nagoya University Graduate School of Medicine, Nagoya, Japan
- Yamaguchi, Makoto, Aichi Medical University, Nagakute, Aichi, Japan
- Katsuno, Takayuki, Aichi Medical University, Nagakute, Aichi, Japan
- Banshodani, Masataka, Tsuchiya General Hospital, Hiroshima, Japan
- Kawanishi, Hideki, Tsuchiya General Hospital, Hiroshima, Japan
Background
Encapsulating peritoneal sclerosis (EPS) is a rare, but life-threatening complication of peritoneal dialysis (PD) therapy. The precise pathogenesis remains unknown, making it difficult to prevent the development of EPS. The aim of this study is to examine the peritoneal samples of EPS patients and identify the association of the peritoneal pathology with different clinical factors.
Methods
Peritoneal samples were obtained at the time of surgical enterolysis in Tsuchiya General Hospital from 1993 to 2016. Total 283 peritoneal samples were screened. This study used pathological and immunopathological techniques to assess EPS peritoneum samples.
Results
214 in 283 samples were evaluable. In conventional PD solution group, the ratio of lumen diameter to vessel diameter (L/V ratio) was significantly smaller (P<0.01) and less angiogenesis (P=0.014). Lower L/V ratio was also found to be related to the relapse of EPS (P=0.014). Univariate analysis demonstrated that L/V ratio was significantly associated with EPS relapse (P=0.024). Multivariate logistic regression analysis suggested that more sever vasculopathy with low L/V ratio was identified as a risk factor of EPS relapse (per 0.1 increase, HR 0.87, P= 0.025)
Conclusion
Pathophysiology of the development of EPS was different between conventional solution and pH-neutral solution. Vasculopathy was related to the development and relapse of EPS in conventional solutions.