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Kidney Week

Abstract: TH-PO607

Muscle Quality Assessment by Texture Analysis on 1H-Magnetic Resonance Images in CKD Patients

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Hur, Lisa, Western University, London, Ontario, Canada
  • Salerno, Fabio R., Western University, London, Ontario, Canada
  • Akbari, Alireza, London Health Sciences Centre, London, Ontario, Canada
  • McIntyre, Christopher W., London Health Sciences Centre, London, Ontario, Canada
Background

Chronic kidney disease (CKD) is associated with reduction in skeletal muscle quality from the interplay of inflammation and malnutrition, resulting in reduced exercise capacity. Muscle quality can be assessed by texture analysis of images acquired by 1H-Magnetic Resonance Imaging (MRI). The study objective is to compare muscle quality using MR images between healthy controls, CKD, hemodialysis (HD) and peritoneal dialysis (PD) patients. We hypothesize that progressive CKD and dialysis therapy are associated with muscle quality changes that can be detected by texture analysis.

Methods

1H T1-weighted images of the calf were acquired on control, CKD, HD, and PD patients. Mid-slice was used to delineate the gastrocnemius and soleus muscle. Heterogeneity of the muscle was quantified by the standard deviation (SD) within the regions. One-way ANOVA was used to assess significance between groups. Pearson correlation analysis was completed between estimated glomerular filtration rate (eGFR) and SD of the muscles at CKD stages 1-5 (HD and PD cohort excluded).

Results

Refer to Figures 1 and 2.

Conclusion

Homogeneous characteristics seen in CKD cohort may be indicative of muscle wasting and fibrosis. MRI based quality assessment may provide potential non-invasive evaluation of the uremic state on skeletal muscle structure and function.

Proton T1-weighted MR image of the calf

Mean SD and standard error bars of (A) gastrocnemius (B) soleus muscle in control, CKD, HD, PD. Pearson correlation of SD and eGFR in (C) gastrocnemius (D) soleus muscle.