Abstract: SA-PO904
Cognitive Impairment, Vascular Dysfunction, and Sedentary Behavior Differ Between Older Adults with and Without CKD
Session Information
- CKD: Clinical, Outcomes, Trials - III
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Hannan, Mary, University of Illinois at Chicago, Chicago, Illinois, United States
- Collins, Eileen, UIC, Hines, Illinois, United States
- Phillips, Shane, University of Illinois, Chicago, Chicago, Illinois, United States
- Steffen, Alana D., University of Illinois at Chicago, Chicago, Illinois, United States
- Bronas, Ulf G., University of Illinois at Chicago, Chicago, Illinois, United States
Background
Chronic kidney disease (CKD) is common in older adults and is associated with numerous complications, including cognitive impairment and vascular dysfunction. Additionally, older adults have lifestyle factors that can negatively influence health, including being sedentary- a phenomenon associated with cognitive impairment, vascular dysfunction, and mortality in the general population. The objective of this study was to determine if there are differences in cognitive impairment, vascular dysfunction, and sedentary behavior between older adults with and without CKD. We hypothesized that older adults with CKD would exhibit cognitive and vascular impairment and be more sedentary, compared to those without CKD.
Methods
Utilizing a cross-sectional approach, 48 older adults (24 with CKD, age 68.4(5.6), eGFR 43.9(11.6)ml/min; 24 without CKD, age 68.5(5.5), eGFR 82.7(12.3) ml/min) were evaluated for performance on a test of global cognition and executive function (Montreal Cognitive Assessment (MoCA)), vascular function via carotid-femoral pulse wave velocity (cfPWV)) and ultrasound (carotid compliance, flow mediated vasodilation), and sedentary behavior via actigraphy. Data was analyzed utilizing t-tests and OLS regression.
Results
Older adults with CKD had higher levels of cognitive impairment and vascular dysfunction and higher sedentary time. In regressions including CKD and the covariates of age, years of education, history of smoking, and gender, the variance was significantly explained for total MoCA score, MoCA executive function score, cfPWV, indicators of carotid compliance, and sedentary time per day.
Conclusion
Cognitive impairment, vascular function, and sedentary behavior in older adults with CKD are different compared to those without CKD. This represents a possible unique phenotypic presentation in this at-risk population.
| Non-CKD | CKD | t | p | R2 | p | |
| n=24 | n=24 | |||||
| MoCA | 26.79 (2.69) | 23.04 (2.93) | 4.62 | <.05 | .3468 | .0003 |
| Executive Function | 4.46 (.78) | 3.29 (.95) | 4.64 | <.05 | .3708 | .0001 |
| cfPWV | 7.45 (.96) | 8.66 (1.65) | -3.02 | .0042 | .2189 | .0148 |
| Distensibility Coefficient | .0028 (.00075) | .002 (.001) | 3.04 | .0038 | .1774 | .0337 |
| Young’s Modulus | 888.77 (324.32) | 1286.6 (489.0) | -3.32 | .0018 | .2089 | .0153 |
| Elastic Modulus | 13017.5 (4059.1) | 17983.5 (7289.4) | -2.92 | .0055 | .1720 | .0384 |
| Sedentary min/day | 654.17 (106.3) | 707.64 (107.3) | -1.72 | .0931 | .2329 | .0092 |
Funding
- Private Foundation Support