Abstract: TH-PO677
Association of Ambulatory Blood Pressure Pattern with Cognitive Function: The SPRINT Ambulatory Blood Pressure Study
Session Information
- Hypertension and CVD: Epidemiology, Risk Factors
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1402 Hypertension and CVD: Clinical, Outcomes, and Trials
Authors
- Rifkin, Dena E., UCSD, San Diego, California, United States
- Pajewski, Nicholas M., Wake Forest, Wake Forest, North Carolina, United States
- Bress, Adam, University of Utah, Salt Lake City, Utah, United States
- Campbell, Ruth C., MUSC, Charleston, South Carolina, United States
- Cushman, William C., Memphis VA Medical Center, Memphis, Tennessee, United States
- Gure, Tanya R., The OSU Wexner Medical Center, Columbus, Ohio, United States
- Haley, William E., Mayo Clinic, Jacksonville, Florida, United States
- Krousel-wood, Marie, Ochsner Clinic Foundation, New Orleans, Louisiana, United States
- Papademetriou, Vasilios, Georgetown University, Potomac, Maryland, United States
- Pisoni, Roberto, Medical University of South Carolina, Charleston, South Carolina, United States
- Weiner, Daniel E., Tufts Medical Center, Boston, Massachusetts, United States
- Wright, Clinton B., National Institute of Neurological Disorders and Stroke, Rockville, Maryland, United States
- Moran, Andrew E., Columbia University Medical Center, New York, New York, United States
- Drawz, Paul E., University of Minnesota, Minneapolis, Minnesota, United States
- Ix, Joachim H., UCSD, San Diego, California, United States
Background
In prior work with healthy older adults, abnormal night-to-day SBP ratio and lower 24 hour diastolic BP on ABPM were associated with worse cognitive function, findings not identified using clinic blood pressures. We examined whether these ABPM parameters were associated with cognitive function in participants in SPRINT, a randomized controlled trial of two different blood pressure targets in hypertensive adults.
Methods
Within SPRINT, 897 participants had 24 hour blood pressure measures collected at the 27 month visit. These readings were within 3 months of a comprehensive cognitive assessment. We examined whether ABPM parameters were associated with scores on the Montreal Assessment of Cognitive Function, logical memory delayed recall, and digit symbol coding test scores, after evaluating for interaction with random treatment assignment. We calculated odds ratios based on a beta-binomial model, with higher odds indicating better cognitive performance.
Results
Mean age was 71.5 ± 9.5, 67% were Caucasian. The intensive BP group had lower SBP and used more BP medication than the standard BP group. On the 3 cognitive tests studied, there was no difference in score between those in the intensive and standard groups, so these were combined. There was no association between night-to-day ratio and cognitive function test scores. After multivariate adjustment there was a modest association between higher diastolic BP (both in clinic and 24-hour) and better cognitive test scores on digit-symbol coding (figure).
Conclusion
Night-to-day blood pressure ratio was not associated with cognition in SPRINT. There was a modest association with diastolic blood pressure both in clinic and over 24 hours. This suggests that in this setting, non-dipping did not strongly associate with scores on cognitive function tests.
Funding
- NIDDK Support