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Abstract: FR-PO437

Erectile Dysfunction Is Associated with increased Coronary Artery Calcification But Not Mortality in Incident Dialysis Patients

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis


  • Roy, Neil, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Yang, Danwen, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Rosas, Sylvia E., Joslin Diabetes Center, Boston, Massachusetts, United States

Erectile dysfunction (ED) is prevalent among the hemodialysis population. Increasing age, diabetes and nonuse of ACE inhibitors has been associated with a higher incidence of ED in our previous work. ED predicts mortality in the general population likely through its association with CVD risk factors.


Objective: To determine the relationship between ED, coronary artery calcification and mortality in incident dialysis patients without prior coronary events using the Dialysis, Heart and Bone Study.
Methods: Sixty-three male participants were enrolled in this prospective study and completed the fifteen-item validated questionnaire, the IIEF-15 as well as MSCT to measure coronary artery calcification. Subjects having a score 25 or less in the self-administered questionnaire were considered to have ED. Detailed information regarding demographics, medical history, and medication usage was obtained by self-report.


The mean age of participants was 49.2 (13.1) years and two-thirds were AA. Forty-four percent of participants had severe ED, 23.8% had moderate ED, 15.8% had mild ED and 15.8% had no ED. The median (IQR) Agatston score was 56.8(0.5-406.5) for those with ED and 0(0-0) for those without ED [p=0.007]. Twenty-three percent of the participants died during an average follow-up of 5 (1.5) years. Twenty-one percent of the participants with ED died compared to ten percent of people without ED (p=0.4). Using a proportional hazard model with covariate adjustment by propensity score, ED was not significantly associated with mortality (p=0.64)


ED is common in new to dialysis patients. ED was significantly associated with increased CAC score. However, it was not associated with increased mortality in incident dialysis patients.