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Abstract: FR-PO437

Erectile Dysfunction Is Associated with increased Coronary Artery Calcification But Not Mortality in Incident Dialysis Patients

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Roy, Neil, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Yang, Danwen, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Rosas, Sylvia E., Joslin Diabetes Center, Boston, Massachusetts, United States
Background

Erectile dysfunction (ED) is prevalent among the hemodialysis population. Increasing age, diabetes and nonuse of ACE inhibitors has been associated with a higher incidence of ED in our previous work. ED predicts mortality in the general population likely through its association with CVD risk factors.

Methods

Objective: To determine the relationship between ED, coronary artery calcification and mortality in incident dialysis patients without prior coronary events using the Dialysis, Heart and Bone Study.
Methods: Sixty-three male participants were enrolled in this prospective study and completed the fifteen-item validated questionnaire, the IIEF-15 as well as MSCT to measure coronary artery calcification. Subjects having a score 25 or less in the self-administered questionnaire were considered to have ED. Detailed information regarding demographics, medical history, and medication usage was obtained by self-report.

Results

The mean age of participants was 49.2 (13.1) years and two-thirds were AA. Forty-four percent of participants had severe ED, 23.8% had moderate ED, 15.8% had mild ED and 15.8% had no ED. The median (IQR) Agatston score was 56.8(0.5-406.5) for those with ED and 0(0-0) for those without ED [p=0.007]. Twenty-three percent of the participants died during an average follow-up of 5 (1.5) years. Twenty-one percent of the participants with ED died compared to ten percent of people without ED (p=0.4). Using a proportional hazard model with covariate adjustment by propensity score, ED was not significantly associated with mortality (p=0.64)

Conclusion

ED is common in new to dialysis patients. ED was significantly associated with increased CAC score. However, it was not associated with increased mortality in incident dialysis patients.