Abstract: TH-PO762
Growth in Children with Non-Glomerular Kidney Disease
Session Information
- Pediatric CKD
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1700 Pediatric Nephrology
Authors
- Park, Eujin, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea (the Republic of)
- Ha, IL-Soo, Seoul National University Children's Hospital, Seoul, Korea (the Republic of)
- Cheong, Hae Il, Seoul National University Children's Hospital, Seoul, Korea (the Republic of)
- Park, Young seo, Asan Medical Center, Songpa-gu, SEOUL, Korea (the Republic of)
- Lee, Joo Hoon, Asan Medical Center, Songpa-gu, SEOUL, Korea (the Republic of)
- Shin, Jae Il, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Cho, Heeyeon, Samsung Medical Center, Seoul, Korea (the Republic of)
- Han, Kyoung Hee, Jeju National University School of Medicine, Jeju, Korea (the Republic of)
- Kim, Seong heon, Pusan National University Children's Hospital, Yangsan, Korea (the Republic of)
- Cho, Min Hyun, Kyungpook National University Hospital, Daegu, Korea (the Republic of)
- Kang, Hee Gyung, Seoul National University Children's Hospital, Seoul, Korea (the Republic of)
Background
Growth retardation is one of common complications of chronic kidney disease (CKD) in children. Children with CKD from non-glomerular disease have been reported to have a higher risk of severe growth retardation than children with glomerular CKD. The objective of this study was to systematically compare growth parameters in children with non-glomerular CKD to those with glomerular CKD.
Methods
Baseline data from 437 children participating in the KoreaN cohort study for Outcomes in patients With Pediatric CKD (KNOW-Ped CKD) were analyzed. Growth was quantified by age-sex-specific height and weight standard deviation scores (SDS). We compared the height and weight SDS in children with non-glomerular CKD (n=325) to those with glomerular CKD (n=112).
Results
Median height and weight SDS in children with non-glomerular CKD was -0.82 [interquartile range (IQR) -7.67 to 2.75] and -0.81[IQR -10.54 to 3.05] while those of glomerular CKD were -0.41[IQR -5.58 to 2.91] and -0.35[IQR -6.72 to 3.44]. 24.9% of the non-glomerular CKD had height SDS below -1.88 (16% in glomerular CKD) and 32.3% had weight SDS below -1.65 (16% in glomerular CKD). 9.5% were using growth hormone (1.8% in glomerular CKD). Non-glomerular CKD patients were significantly shorter and lighter than glomerular CKD, and proportion of short stature and proportion of underweight were larger in non-glomerular CKD than glomerular CKD. When further grouped according to age, children younger than 2 years-old with non-glomerular CKD were the shortest and the most underweighted (median height SDS -2.04; IQR -6.86 to 1.95, median weight SDS -2.32; IQR -6.76 to 1.83). Significance of non-glomerular CKD was also found in analysis of risk factors for growth impairment; In multivariable analysis, the most significant risk factor of underweight was non-glomerular CKD, followed by anemia and proteinuria. In turn, underweight itself was the most important risk factor for height impairment in children with CKD.
Conclusion
In concordance with the previous report, children with non-glomerular CKD have a high prevalence of growth abnormalities in the KNOW-Ped CKD cohort. In this population, more intensive and early intervention through growth hormone treatment and nutritional supplementation is necessary, especially in young children with non-glomerular CKD.
Funding
- Government Support - Non-U.S.