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Abstract: FR-PO878

Pregnancy Outcomes in Patients with Systemic Lupus Erythematosus with or Without Lupus Nephritis

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Ohishi, Yuko, Gunma University, Maebashi, GUNMA, Japan
  • Ikeuchi, Hidekazu, Gunma University Graduate School of Medicine, Maebashi, Japan
  • Hamatani, Hiroko, Gunma University, Maebashi, GUNMA, Japan
  • Nakasatomi, Masao, Gunma University, Maebashi, GUNMA, Japan
  • Sakairi, Toru, Gunma University Graduate School of Medicine, Maebashi, Japan
  • Kaneko, Yoriaki, Gunma University Graduate School of Medicine, Maebashi, Japan
  • Maeshima, Akito, Jichi Medical University, Shimotsuke, TOCHIGI, Japan
  • Hiromura, Keiju, Gunma University Graduate School of Medicine, Maebashi, Japan
Background

Systemic lupus erythematosus (SLE) affects the pregnancy. Previous paper showed an increased risk of premature birth in patients who had a history of lupus nephritis. In the present study, we examined the outcomes of pregnancy in SLE patients with lupus nephritis (renal SLE) or without lupus nephritis (non-renal SLE).

Methods

We retrospectively examined 94 pregnancies in 53 SLE patients who treated in our department from January 1996 to March 2018.

Results

Mean patient age and serum creatinine at the beginning of pregnancy were not significantly different between renal and non-renal SLE patients: 29.4±5.8 vs 30.4±3.2 (years) and 0.48±0.11 vs 0.51±0.12 (mg/dL). Outcomes of pregnancy were shown in Table 1. Percentage of premature birth and low birth weight were more frequent in SLE patients in total, compared to the reported data of general population in Japan (19% vs 6% and 36% vs 10%, respectively). However, there were no significant differences between renal and non-renal SLE. Frequency of fetal loss was also not different between 2 groups, although natural abortion + stillbirth tended to be more in renal SLE than non-renal SLE (19% vs 4%, p=0.135). Among 43 renal SLE patients, 9 patients already had proteinuria at the beginning of pregnancy. Renal flare was observed in 5 patients (15%) out of 34 renal SLE patients without proteinuria at the beginning. In addition, pregnancy-induced hypertension was observed in 2 renal SLE patients (5%) and 3 non-renal SLE patients (6%).

Conclusion

In our study, frequencies of premature birth and fetal loss were not different between renal and non-renal SLE patients. However, both renal and non-renal SLE patients had higher rate of premature birth and low weight birth, compared to general population.