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Abstract: FR-PO439

Atheromas and Peripheral Vessel Physiology in Relation to Culinary Habits in ESRD: Diversion Between Peritoneal Dialysis and Hemodialysis Population by Adopting the Mediterranean Diet Regime

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Giannou, Panagiota E., General Hospital of Athens "Hippokration:, Athens, Greece
  • Angelis, Athanasios, Hippokration Hospital, 1rst Department of Cardiology, University of Athens , Greece, Athens, Greece
  • Aggeli, Constantina, Hippokration Hospital, 1rst Department of Cardiology, University of Athens , Greece, Athens, Greece
  • Kapota, Athanasia, General Hospital of Athens "Hippokration:, Athens, Greece
  • Stambolliu, Emelina, General Hospital of Athens "Hippokration:, Athens, Greece
  • Vlachopoulos, Charalambos, Hippokration Hospital, 1rst Department of Cardiology, University of Athens , Greece, Athens, Greece
  • Petras, Dimitrios I., General Hospital of Athens "Hippokration:, Athens, Greece
Background

End stage renal disease (ESRD) relates to atheroma formation and typically amplifies cardiovascular risk. Patients on hemodialysis (HD) impose strict dietary restrictions. On the contrary, patients on peritoneal dialysis (PD) may consume a wide variety of alimentary goods.

Methods

92 male ESRD patients, 52 of them on HD and the rest 40 on PD without apparent cardiovascular disease were matched to enroll the study. The 2 groups did not differ statistically in age, (64,9 ± 15.2 vs 64 ± 11.4) prevalence of hypertension, diabetes mellitus, smoking and lipid profile. All underwent common carotid ultrasound examination for detecting plaque formation and intima –media thickness (IMT) evaluation as indices of subclinical atheromatosis. Peripheral vessel rheology was assessed by the SHIM-5 score that grades erectile potency. A lower score indicates severe erectile dysfunction unmasking thus endothelial dysfunction.Dietary habits were evaluated through a special diet score (Med-Diet score, range 0-55), which assesses adherence to the Mediterranean diet. Lower values indicate poor adherence to this alimentary pattern.

Results

Patients on HD had statistically higher IMT (1.5 ± 0.7 vs 0.85 ± 0.2), lower SHIM-5 score grading (8.8 ± 6.9 vs 12.8 ±4.5) and lower Med-Diet score(22 ± 4 vs 29 ±3) as compared to PD patients (all P<0.05). Carotid IMT and carotid plaque formation were inversely associated (r=-0.32, P<0.01) and SHIM-5 was positively correlated (r=0.29, P<0.01) to the Med-diet score. The associations remained significant in linear regression analysis after adjustment for age, body mass index, presence of hypertension, diabetes mellitus, tobacco use and statin therapy (all P<0.01).

Conclusion

ESRD male patients on peritoneal dialysis may exhibit lower atheromatic load and enhance peripheral vessel rheology by adopting the Med-diet regime. Healthy dietary choices may improve quality of life and cardiovascular outcome in this specific ESRD population.