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Abstract: FR-PO537

Interesting Relationship Between Levels of Thioredoxin and Vitamin D on Antioxidant System in Peritoneal Dialysis Patients

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Author

  • Yavuz Ileri, Sara, Yeditepe University, Istanbul, Turkey
Background

The reactive oxygen species produced continuously during oxidative metabolism are generated at very high rates in chronic kidney failure. Therefore, defending against oxidative stress is an essential task with the patients who suffering from that disease. An important cellular system against oxidative stress is the cytosolic mammalian thioredoxin system (TS) which consist of thioredoxin ( trx), nicotinamide adenine dinucleotide phospate (NADPH) and thioredoxin reductase (TrxR) has emerged as a major anti-oxidant which involved in the maintenance of cellular physiology and survival. Vitamin D is also an other strong antinflammatory molecule and it has a growing of number of studies revealing its pleiotropic roles beyond the bone and calcium metabolism. The aim of this study is to find a significant relation between these two systems.

Methods

We conducted a study of 69 patients with end stage of kidney disease who were under the treatment of continuous ambulatory peritoneal dialysis or automated peritoneal dialysis . Serum thioredoxin level were measured.
Measurements were corrected according to comorbid diseases, medications, duration and type of peritoneal dialysis and residual renal function. In addition, they were also evaluated for the correlation between hemoglobin, uric acid, CRP, albumin, ferritin, lipid parameters and iPTH levels.Our aim was to prove the effect of the use of Vitamin D supplementation on thioredoxin as an anti-oxidant system. 40 out of 62 patients were already under the vit D supplemantation but the rest of the group was not eligible.

Results

There was no statistically significant difference between Thioredoxin measurements according to PD type , etiology and drugs (p> 0.05) but Thioredoxin levels in patients with vit D supplemantation were significantly higher than those without vit D supplemantation. (p <0.01). The results were evaluated in a confidence interval of 95% and a significance level of p <0.05.

Conclusion

This result of study was not suprising but important because it emphasized that Vit D anti-inflammatory effect especially in chronic kidney failure patients except the bone-mineral metabolism and pointed to strict follow –up vit D level in this group which is already under the inflamatory situation to reduce complications related to oxidative stress by contributing the augmentation of thioredoxin serum level.