Kidney Week

Abstract: TH-PO423

Associations Between Long-Term Ambient PM_2.5 Exposure and Prevalence of CKD: An Analysis Based on the China National Survey of CKD

Session Information

• CKD: Risk Scores and Translational Epidemiology
  November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Wang, Jinwei, Renal Division, Department of Medicine, Peking University First Hospital; Peking University Institute of Nephrology, Beijing, BEIJING, China

Jinwei Wang,

• Huang, Jing, Peking University School of Public Health, Beijing, China

Jing Huang,

• Li, Guoxing, Peking university, Beijing, China

Guoxing Li,

• Zhao, Ming Hui, Peking University First Hospital, Beijing, China

Ming Hui Zhao,

• Zhang, Luxia, Peking University Institute of Nephrology, Beijing, China

Luxia Zhang,

Background

Our aim is to explore the associations between long-term exposure to ambient PM_2.5 and prevalence of chronic kidney disease (CKD) based on the China National Survey of CKD.

Methods

A sample of 47,204 people representing general adult population in China were recruited from January 2007 to October 2010. Annual exposure to satellite derived PM_2.5 (obtained from the Aerosol Optical Depth Database) prior to the survey date (2 years range) was estimated at each participant's address using validated satellite-based spatiotemporal model with 10km×10km resolution. Participants with estimated glomerular filtration rate <60 mL/min/1.73 m² and/or urinary albumin creatinine ratio≥30mg/g were defined as CKD. Generalized additive mixed effects models were used to estimate the associations, and the influence of the potential modifiers were also analyzed.

Results

The overall prevalence of CKD was 10.8%. Two-year mean PM_2.5 concentration was 57.41 μg/m³, with a range from 31.25 to 87.49 μg/m³. Per 10 μg/m³ increase in PM_2.5 was positively associated with the prevalence of CKD with adjusted OR of 1.33 (95%CI: 1.25, 1.41). The exposure-response curve showed relatively steep at low levels of exposure and flattened out at higher exposures (Figure). Similar findings were detected for albuminuria. Stratified analyses indicated the associations were stronger in the smokers than non-smokers, in the young people versus the elderly, and were stronger in participants without comorbid diseases than those with comorbid diseases including diabetes, hypertension, obesity, and cardiovascular history.

Conclusion

This study showed a significant association between long-term PM_2.5 exposure with broad range and increased prevalence of CKD in the national representative general population.

The exposure-response curve between long-term exposure to ambient PM_2.5 and prevalence of CKD

Funding

• Government Support - Non-U.S.