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Abstract: TH-OR053

Glomerular Hyperfiltration Predicts Cardiovascular Outcomes in Apparently Healthy Individuals

Session Information

Category: CKD (Non-Dialysis)

  • 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

  • Dupuis, Marie-Eve, Université de Montréal, Montréal, Quebec, Canada
  • Nadeau-Fredette, Annie-Claire, Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada
  • Madore, Francois, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada
  • Agharazii, Mohsen, CHUQ-HDQ, Quebec City, Quebec, Canada
  • Goupil, Remi, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada
Background

Glomerular hyperfiltration (GHF) is associated with increased risk of cardiovascular (CV) diseases in high risk conditions, but its significance in low risk individuals is uncertain. The aim of this study was to determine the CV risk associated with GHF in apparently healthy individuals.

Methods

9,515 apparently healthy individuals without hypertension, diabetes, CV disease, stages 3-5 CKD and statin/aspirin with available follow-up data (governmental database) were identified from a large population study. From these, patients with GHF (eGFR > 95th percentile after stratification for sex/age) were compared to controls (eGFR 25th to 75th percentiles). Cardiovascular events (CVE) included CV mortality, myocardial infarction, unstable angina, heart failure, stroke and transient ischemic attack. CVE risk was assessed using Cox proportional hazard model and fractional polynomial regression.

Results

Baseline characteristics of individuals with GHF [eGFR 102 (95% CI 107, 115) ml/min/1.73m2] and normal filtration [eGFR 92 (87, 97)] are presented in Table 1. During a median follow-up of 70 months, 245 CVEs occurred. GHF was associated with an increased risk of CVE [HR 1.78 (1.19, 2.64), p=0.005; Figure 1]. When evaluated continuously, only the highest eGFR percentiles were associated with increased CV risk (Figure 2).

Conclusion

GHF is independently associated with increased CVE risk in apparently healthy individuals. Whether this association is causal or not remains to be determined.