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Abstract: TH-PO1179

Glomerular Filtration Rate Measurement by Iohexol Plasma Clearance in an Ethnically Diverse Living Donor Population

Session Information

Category: Transplantation

  • 1902 Transplantation: Clinical

Authors

  • Wiegley, Nasim, University of California, Davis, Sacramento, California, United States
  • Huang, Yihung, University of California, Davis, Sacramento, California, United States
  • Chen, Ling-Xin, University of California, Davis, Sacramento, California, United States
Background

Iohexol is a good agent for measurement of GFR (mGFR) due to its low extrarenal excretion, tubular secretion or reabsorption, and protein binding affinity. We compared mGFR by plasma clearance of iohexol with serum creatinine (sCr) based GFR estimations in our living kidney donor candidates and investigated the association between GFR and donor demographic characteristics.

Methods

All potential living donors with GFR measurement by iohexol plasma clearance at our center between 10/2016 – 4/2019 were included. Linear regression was performed for comparison of mGFR by ethnicity, sex, age, and BMI. Medical records were reviewed for age, BMI, ethnicity, and sCr to calculate eGFR by CKD-EPI and MDRD.

Results

Of 407 potential living donors evaluated, 35% were men and the mean age was 42. Racial distribution: 47% Caucasian, 29% Hispanic, 28% Asian, 4% Black. Median mGFR was 102 ml/min/1.73m2. Median mGFR was higher for Hispanics (106) and Asians (108) compared to Caucasians (96) [Figure1]. Women > 50yrs had faster mGFR decline than men the same age. Correlation between mGFR and sCr-based eGFR showed that CKD-EPI had a closer correlation (slope=0.42, R = 0.27) than MDRD (slope=0.37, R =0.25) [Figure 2]. Compared with Caucasians, Hispanics had higher mGFR than eGFR by CKD-EPI. Both Hispanics and Asians had higher mGFR compared to eGFR by MDRD.

Conclusion

Hispanic and Asian ethnicities have higher mGFR compared to Caucasians in our potential living donor population, which is an important finding that requires further delineation. CKD-EPI and MDRD eGFR calculations may also underestimate mGFR when used in these ethnicities.