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Abstract: FR-PO141

Impact of Parathyroidectomy on Left Ventricular Function in ESRD Patients

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical

Authors

  • Chen, Shaohua, Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ZHEJIANG, China
  • Shen, Ying, Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ZHEJIANG, China
  • Zhang, Ping, Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ZHEJIANG, China
  • Jiang, Hua, Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ZHEJIANG, China
  • Lei, Xin, Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ZHEJIANG, China
  • Qu, Lihui, Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ZHEJIANG, China
  • Xu, Chunping, Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ZHEJIANG, China
  • Chen, Jianghua, Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ZHEJIANG, China
Background

Secondary hyperparathyroidism is a common complication in End Stage Renal disease patients,and parathyroidectomy is an effective treatment of SHPT. The biochemical parameters and clinical symptoms has been proven to be drastically improved after the surgery,but the curative impact of parathyroidectomy on left cardiac function is still controversial.To evaluate the impact of parathyroidectomy on left cardiac function in ESRD patient,we conducted this retrospective study.

Methods

We collected and analyzed the basic data including serum calcium,phosphor,ALB, PTH,alkaline phosphatase(ALP) pre and post-operation ,and the ultrasonic cardiogram including EF,FS,LA,AO,LVSd,LVSs,LVDd,LVDs,PWd,PWs,LVM and LVMI before and after 1 year of patients who accepted total parathyroidectomy (PTX) with forearm Autograft.

Results

There were totally 135 patients invovled,all of whose postoperative serum calcium,phosphor, PTH,ALB has been obviously improved compared with preoperative group,but the statistical change of EF and FS which stand for left cardiac function after 1 year didn’t exist. We then carried out a further subgroup analysis,picking out patients whose EF were lower than or equal to 60%(n=35) before the surgery. Compared with preoperative group,the EF,FS of postoperative group increased, and LVDs,LVM.LVMI declined(p<0.05).

Conclusion

PTX+AT is an effective curative method to secondary hyperparathyroidism which can significantly improve the postoperative biochemical parameters. For patients whose EF≤60%,PTX+AT can markedly increase their left cardiac function.