Kidney Week

Abstract: TH-PO705

Association of Noninvasive Measures of Subclinical Atherosclerosis and Arterial Stiffness Cardiovascular Risk with Mortality and Cardiovascular Events in CKD: A Meta-Analysis

Session Information

• Hypertension and CVD: Epidemiology, Risk Factors
  November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

• Kouis, Panayiotis, University of Cyprus, Nicosia, Cyprus

Panayiotis Kouis,

• Kousios, Andreas, Imperial College Healthcare NHS Trust, London, United Kingdom

Andreas Kousios,

• Kanari, Athina, Cyprus University of Technology, Limassol, Cyprus

Athina Kanari,

• Kleopa, Daphne, Cyprus University of Technology, Limassol, Cyprus

Daphne Kleopa,

• Papatheodorou, Stefania, Cyprus University of Technology, Limassol, Cyprus

Stefania Papatheodorou,

• Panayiotou, Andrie G., Cyprus University of Technology, Limassol, Cyprus

Andrie G. Panayiotou,

Background

<p style="margin: 0px 0px 13.33px;"><span lang="EN-US" style="font-family:times new roman,serif; margin:0px"><font color="#000000" size="3">Non-invasive Cardiovascular disease (CVD) risk prediction, in subclinical stages, aiming to stratify patients and tailor interventions remains an unmet need in CKD. We summarize the association of carotid intima-media thickness (cIMT), coronary artery calcium score (CACS) and pusle-wave velocity with all-cause mortality, CVD mortality and CVD events in non-dialysis CKD and patients on dialysis. </font></span></p>

Methods

Systematic review and metanalysis of prospective cohort studies.

Results

24 out of 27984 studies were eligible for quantitative synthesis (5 for cIMT, 11 for CACs and 8 for PWV) involving 708, 3706 and 4393 patients respectively.

In dialysis patients, cIMT was associated with all-cause mortality (relative risk (RR) per unit increase 1.08, 95% confidence interval (CI) 1.00-1.17, I²:68%) and CVD mortality (RR: 1.29, 95% CI 1.14-1.47, I²:0%). High Vs low CACS was associated with all-cause mortality (RR: 2.51, 95% CI: 1.66-3.79, I²: 5.7%) and CVD events (RR: 3.77 95% CI: 2.16-6.58, I²: 20.2%). High Vs low PWV was associated with all-cause (RR: 5.34, 95% CI 3.01-9.47, I²: 0%) and CVD mortality (RR: 8.55, 95%CI: 4.37 to 16.73, I²: 0%). The combined estimated for all-cause mortality per 1 m/s increment unit in PWV, was 1.25 (95%CI: 1.17-1.34, I²: 0%) and for CVD mortality was 1.24 (95%CI: 1.16-1.34, I²: 15.5%).

In non-dialysis patients, CACs was associated with CVD events (RR: 4.02, 95%CI: 1.57-10.29, I²: 63.4%). High Vs low PWV was associated with all-cause mortality (RR: 2.52, 95% CI 1.40-4.55, I²: 62.6%).

Conclusion

cIMT, CACS and PWV are associated with all-cause, CVD mortality and events among patients with all stages of CKD. These markers could be considered for the evaluation of cardiovascular morbidity and mortality risks.