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Abstract: TH-PO082

An Evaluation of the Prevalence of Kidney Diseases in Patients with Inflammatory Bowel Diseases in a Nationwide Analysis

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Saha, Manish K., UNC Kidney Center, Chapel Hill, North Carolina, United States
  • Barnes, Edward L., University of North Carolina, Chapel Hill, North Carolina, United States
  • Falk, Ronald J., UNC Kidney Center, Chapel Hill, North Carolina, United States
  • Nachman, Patrick H., University of Minnesota, Minneapolis, Minnesota, United States
  • Isaacs, Kim L., University of North Carolina, Chapel Hill, North Carolina, United States
  • Thorpe, Carolyn T., University of North Carolina, Chapel Hill, North Carolina, United States
  • Hogan, Susan L., University of North Carolina, Chapel Hill, North Carolina, United States
  • Kshirsagar, Abhijit V., University of North Carolina, Chapel Hill, North Carolina, United States
Background

Up to 40% of patients with Inflammatory bowel diseases(IBD) may have extra-intestinal manifestations,mainly involving liver,skin,and joints. Anecdotal reports suggest renal involvement, but there are no estimates of prevalence.Our aim was to examine the prevalence of kidney diseases among hospitalized patients with IBD, along with the prevalence of kidney disease among patient with collagen vascular diseases (CVD) and among patients without IBD and CVD

Methods

We analyzed 2000-2014 data from the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample database which captures annual hospital discharge data for 20% stratified sample of U.S.community hospitals.We used International Classification of Diseases,Ninth Revision,diagnosis codes to identify three subsamples.Kidney diseases include acute kidney injury,glomerular diseases and others.CVD included systemic lupus erythematosus,rheumatoid arthritis and others.

Results

Among 713,902 hospitalized IBD patients,we identified 69,049 individuals with kidney diseases(9.6%),representing a weighted national estimate of 341,946 individuals with kidney diseases.The prevalence of kidney disease among patients with IBD was 9.6%,11.9% in patients with CVD, and 8.5% in the general population (all p<0.001).Baseline characteristics of patients in three groups are given in Table1.Patients with IBD had a younger age distribution,higher distribution of white race,and a lower prevalence of hypertension,diabetes,and CHF when compared to patients with CVD or the general population without IBD or CVD

Conclusion

The burden of renal disease among patients with IBD is greater than that of the general population,which is notable given their lower traditional risk factors for kidney disease;and similar to CVD which is an immune-mediated systemic disorder.Coexisting renal disease should be considered among patients with a known diagnosis of IBD

Table1