Abstract: TH-PO1015
Sex-Related Disparities in IgA Nephropathy Progression
Session Information
- Glomerular Diseases: Minimal Change Disease, FSGS, IgAN
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1203 Glomerular Diseases: Clinical, Outcomes, and Trials
Authors
- Koshino, Akihiko, Department of Nephrology,Kanazawa University Hospital, Kanazawa, Japan
- Ogura, Hisayuki, Department of Nephrology,Kanazawa University Hospital, Kanazawa, Japan
- Sato, Koichi, Department of Nephrology,Kanazawa University Hospital, Kanazawa, Japan
- Miyagawa, Taro, Department of Nephrology,Kanazawa University Hospital, Kanazawa, Japan
- Kitajima, Shinji, Department of Nephrology,Kanazawa University Hospital, Kanazawa, Japan
- Hara, Akinori, Department of Nephrology,Kanazawa University Hospital, Kanazawa, Japan
- Iwata, Yasunori, Department of Nephrology,Kanazawa University Hospital, Kanazawa, Japan
- Sakai, Norihiko, Department of Nephrology,Kanazawa University Hospital, Kanazawa, Japan
- Furuichi, Kengo, Kanazawa Medical University, Kahoku-Gun, Japan
- Wada, Takashi, Department of Nephrology,Kanazawa University Hospital, Kanazawa, Japan
Background
Sex related disparities in prognosis of CKD has been reported. We investigated the influence of gender on prognosis in immunoglobulin A nephropathy(IgA) nephropathy.
Methods
This was a multi-center retrospective study. Patients were divided into two groups according to gender. The clinical features at renal biopsy and renal outcomes during the follow-up were collected and analyzed. Renal outcomes were defined as 30% estimated glomerular filtration rate (eGFR) decline from base line. The prognostic effects of gender were evaluated by Cox regression models
Results
Total of 238 eligible patients with IgA nephropathy were enrolled (male: 124, female: 114). Male patients had higher body mass index and HDL cholesterol levels than female patients. There was no statistical difference on other features including age, blood pressure, eGFR and proteinuria. Median follow-up period was 88 (43 - 133) months. In survival analysis, male showed higher hazard ratio (HR) of 30% eGFR decline than female (HR 1.8, 95% confidence interval(CI): 1.1-3.4, p=0.03). Multivariable Cox regression analyses matched BMI and HDL cholesterol revealed that gender was also detected as a prognostic factor (HR 1.4, 95% CI 1.1-2.2, p=0.02). In gender-based survival analysis, eGFR and proteinuria are common risk factors of 30% eGFR decline. In particular, hypertension in men and lower HDL cholesterol in women was gender specific risk factor of 30% eGFR decline.
Conclusion
Sex related disparities in progression of IgA nephropathy was suggested.