Kidney Week

Abstract: SA-PO818

Resistant Starch Supplementation Attenuates Inflammation in Hemodialysis Patients

Session Information

• Health Maintenance, Nutrition, Metabolism - II
  November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1300 Health Maintenance, Nutrition, and Metabolism

Authors

• Mafra, Denise, Federal University Fluminense, Rio de Janeiro, RIO DE JANEIRO, Brazil

Denise Mafra,

• Paiva, Bruna, Federal University Fluminense, Rio de Janeiro, RIO DE JANEIRO, Brazil

Bruna Paiva,

• Esgalhado, Marta, Federal University Fluminense, Rio de Janeiro, RIO DE JANEIRO, Brazil

Marta Esgalhado,

• Borges, Natalia Alvarenga, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil

Natalia Alvarenga Borges,

• Kemp, Julie ann, Federal University Fluminense, Rio de Janeiro, RIO DE JANEIRO, Brazil

Julie ann Kemp,

• Cardozo, Ludmila Fmf, Federal Fluminense University, Niterói, Rio De Janeiro, Brazil

Ludmila Fmf Cardozo,

• Brito, Jessyca Sousa de, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil

Jessyca Sousa de Brito,

• Leite, Paulo emílio Corrêa, INMETRO, Rio de Janeiro, RJ, Brazil

Paulo emílio Corrêa Leite,

• Macedo, Renata De azevedo, Federal Fluminense University, Niterói, Rio De Janeiro, Brazil

Renata De azevedo Macedo,

• Alves, Gutemberg G., Fluminense Federal University, Rio de Janeiro, RJ, Brazil

Gutemberg G. Alves,

Group or Team Name

• Nutrição em Nefrologia

Background

Dysbiosis in chronic kidney disease (CKD) is linked to oxidative stress and inflammatory response. Researchers have investigated strategies capable of reestablishing the symbiosis of the gut microbiota in CKD, and suggested that resistant starch (RS) can promotes many benefits, including immunomodulatory effects. The aim of the study was to evaluate the impact of RS supplementation on levels of some inflammatory markers in hemodialysis (HD) patients.

Methods

A double-blind, placebo-controlled, randomized trial was conducted with sixteen HD patients [55.3 ± 10.0 years, BMI, 25.9 ± 5.42 kg/m², 56% men, time on dialysis 38.9 ± 29.2 months] that were equally divided in RS (16 g of RS HI-MAIZE 260, Ingredion®) or placebo (manioc flour) groups, to receive alternately 9 cookies/day (dialysis days) and 1 sachet/day (non-dialysis days) for 4 weeks. Cytokines and growth factors plasma levels were evaluated by XMap-labeled magnetic microspheres based multiparametric immunoassay (LuminexCorp, USA), before and after supplementation.

Results

After RS supplementation there was a reduction of Normal T Cell Expressed and Secreted (RANTES) (p<0.001), Platelet-derived growth factor two B subunits (PDGF-BB) (p=0.014) and Interferon-inducible protein 10 (IP-10) (p=0.027) (Fig 1). The other parameters did not change significantly.

Conclusion

The results of this randomized study suggested that supplementation with prebiotic, specifically RS, was able to minimize the inflammation in CKD patients on HD. These findings support the hypothesis that the use of prebiotics can be an effective non-pharmacological intervention in reducing the inflammatory state in CKD patients.

Funding

• Government Support - Non-U.S.