Abstract: SA-PO1166
Recipient ABO Blood Group May Be Associated with Increased Mortality Risk Among Patients with Kidney Transplants
Session Information
- Transplantation: Clinical - Rejection, Recurrent Disease, Incompatibility
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Ng, Monica S., Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
- Ullah, Shahid, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia
- Wilson, Gregory John, Princess Alexandra Hospital, Brisbane, Queensland, Australia
- McDonald, Stephen P., South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia
- Sypek, Matthew P., South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia
- Mallett, Andrew John, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
Background
Blood groups A and B have been associated with increased risks of cardiovascular disease, infection and cancers. To date, the effect of recipient ABO blood group on patient survival has not been studied in ABO-matched solid organ transplantation.
Methods
All Australian and New Zealand transplant recipients who received ABO-compatible primary kidney transplant between 1995-2016 were analysed using data from the Australia and New Zealand Dialysis and Transplant (ANZDATA) registry. The exposure was recipients’ ABO blood group, with the primary analysis being O / non-O and secondary analysis Individual blood groups. Outcome was patient survival. Recipient age, gender, ethnicity, body mass index, smoking status, comorbidities, primary kidney disease; donor type, age and gender; and transplant era were included in the multivariate model as confounders.
Results
On analysis of 15,523 kidney transplant recipients, blood group O was not associated with patient survival (hazard ratio (HR) 0.97, 95% confidence interval (CI) 0.91-1.05) compared to non-blood group O recipients. Blood group A was associated with reduced patient survival compared to non-blood group A recipients (HR 1.10, 95% CI 1.02-1.18).
Conclusion
This analysis suggests that blood group A recipients may have reduced patient survival compared to non-A recipients. Further research is required to confirm these findings and determine the source of this difference – be it biological or unmeasured confounders.