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Abstract: FR-PO440

Association of Serum Indoxyl Sulfate Level with Peripheral Artery Occlusive Disease in Patients with Hemodialysis

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Lin, Lin, Buddhist Tzu Chi General Hospital, Hualien, Select a state/province, Taiwan
  • Chiu, Liang-Te, Buddhist Tzu Chi General Hospital, Hualien, Select a state/province, Taiwan
  • Hsu, Bang-Gee, Buddhist Tzu Chi General Hospital, Hualien, Select a state/province, Taiwan
Background

Indoxyl sulfate (IS) can be considered as a cardiovascular toxin and a nephrotoxin that has been associated with intima media thickness, vascular disease, coronary artery disease, progression of kidney disease and increased mortality. Peripheral arterial occlusive disease (PAOD) is associated with an increased risk of death in hemodialysis (HD) patients. The aim of this study was to evaluate the relationship between IS level and PAOD by ankle-brachial index (ABI) in HD patients.

Methods

Blood samples were obtained from 80 chronic HD patients. Serum total IS level was performed with high-performance liquid chromatography and mass spectrometry. ABI values were measured using the automated oscillometric method (VaSera VS-1000). ABI values that were < 0.9 were included in the low ABI group.

Results

Among the 80 HD patients, 12 of them (15.0%) were in the low ABI group. Compared with patients in the normal ABI group, the patients in the low ABI group had higher prevalence of diabetes (P = 0.010), higher serum C-reactive protein (P < 0.001), and IS (P < 0.001) levels, while lower had statin used (P = 0.042). In addition, the multivariable logistic regression analysis showed that serum IS (Odds ratio [OR]: 1.115, 95% confidence interval [CI]: 1.015-1.225, P = 0.023) and CRP levels (each increase 0.1 mg/dL, OR: 1.187, 95% CI: 1.046-1.346, P = 0.008) were the independently associated with PAOD in HD patients. The area under the receiver-operating characteristic (ROC) curve predicting PAOD by serum IS level in HD patients was 0.800 (95% CI: 0.696-0.881, P = 0.0002).

Conclusion

In this study, serum total IS level was found to be associated with PAOD in HD patients.