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Kidney Week

Abstract: TH-PO669

Geriatric Renal Transplantation in India: A Single-Centre Experience

Session Information

  • Geriatric Nephrology
    November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Geriatric Nephrology

  • 1100 Geriatric Nephrology

Authors

  • Bhargava, Vinant, Sir Ganga Ram Hospital , New Delhi, India
  • Agrawaal, Krishna Kumar, Nepal Medical College and Teaching Hospital, Parasi-5, Nepal
  • Meena, Priti, Sir Ganga Ram Hospital , New Delhi, India
  • Bhalla, Anil, Sir Ganga Ram Hospital , New Delhi, India
  • Gupta, Ashwani, Sir Ganga Ram Hospital , New Delhi, India
  • Gupta, Anurag, Sir Ganga Ram Hospital , New Delhi, India
  • Rana, Devinder S., Sir Ganga Ram Hospital , New Delhi, India
  • Malik, Manish, Sir Ganga Ram Hospital and GRIPMER, New Delhi, India
Background

Kidney transplantation is a deterrent all over the world in the elderly due to higher cardiovascular mortality and infections. Death censored allograft survival appears to be similar in elderly and young.

Methods

Data of elderly (age ≥60 years) patients who underwent renal transplant was assessed. Changes in renal function, complications, graft rejection and mortality over 12 months post-transplant were determined.

Results

In 71 patients, mean age was 63.3±3.5 years and 88.7% were females. Diabetic kidney disease (40.8%) was most common aetiology for renal failure. Serum creatinine (SrC) in immediate post-transplant period was 1.2±0.8 mg/dl. In follow-up, no significant change in SrC was observed at 3 months (1.2±0.7 mg/dl, p=0.458), 6 months (1.4±0.9 mg/dl, p=0.234), 9 months (1.4±0.9 mg/dl, p=0.148) and 12 months (1.5±1.0 mg/dl, p=0.105) in comparison to baseline value. Proportion of patients with SrC ≥ 2 mg/dl increased from 5.6% at baseline to 12.7% at 12 months. Overall, 39.4% patients developed one or more infections of which urinary tract infections (22.5%) were most common. Cytomegalovirus (CMV) and lower respiratory tract infections were observed in three (4.2%) patients each. Acute graft rejection occurred in three (4.2%) patients. Six (8.5%) patients died during the 12 months follow-up period. Among non-survivors, two patients died during hospital stay and infections were major cause for mortality.

Conclusion

In the elderly patients who underwent renal transplant, graft function was well maintained over 12 months. Urinary infections are of common occurrence. Rates of acute rejection and mortality were comparable to the literature from India.