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Abstract: FR-PO1152

A Cross-Sectional Prospective Study of High Serum Adipocyte Fatty Acid Binding Protein Level Associated with Low Handgrip Strength in Renal Transplant Recipients

Session Information

Category: Transplantation

  • 1902 Transplantation: Clinical

Authors

  • Lin, Lin, Buddhist Tzu Chi General Hospital, Hualien, Select a state/province, Taiwan
  • Chiu, Liang-Te, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
  • Hsu, Bang-Gee, Buddhist Tzu Chi General Hospital, Hualien, Select a state/province, Taiwan
Background

Adipocyte fatty acid-binding protein (A-FABP) involved in lipid metabolism and metabolic and inflammatory responses and can accelerate cardiovascular disease. Low muscle strength is related to functional limitations and physical disability and is associated with all-cause mortality. The present study evaluated the relationship between fasting serum A-FABP level and handgrip strength (HGS) in renal transplant recipients.

Methods

Fasting blood samples were collected from 80 renal transplant recipients. HGS was measured using a Jamar Plus Digital Hand Dynamometer for assessment of muscle strength. Low muscle strength was defined as HGS less than 26 Kg for men and 18 Kg for women, according to the Asian Working Group for Sarcopenia (AWGS) criteria. Serum A-FABP levels were determined using a commercially available enzyme immunoassay.

Results

Thirty-one renal transplant recipients (38.8%) had low HGS, and they included a higher percentage of patients with diabetes (P = 0.025), serum triglyceride (P = 0.003), fasting glucose (P = 0.009), blood urea nitrogen (P = 0.003), creatinine (P = 0.005), and A-FABP level (P < 0.002), while lower estimated glomerular filtration rate (P = 0.008) compared with renal transplant recipients with normal HGS. After adjusting for factors significantly associated with low HGS in these patients by multivariate logistic regression analysis, serum A-FABP level (Odds ratio (OR): 1.037, 95% confidence interval (CI): 1.012–1.064, P = 0.004) was independently associated with low HGS in renal transplant recipients. The serum A-FABP level is also statistically significant in male renal transplant recipients (OR: 1.052, 95% CI: 1.000–1.107, P = 0.049) and female renal transplant recipients (OR: 1.132, 95% CI: 1.008–1.272, P = 0.037) after multivariate logistic regression analysis.

Conclusion

The serum fasting A-FABP level is positively associated with low HGS in renal transplant patients.