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Kidney Week

Abstract: TH-PO930

Association of Low Serum Adiponectin Levels with Aortic Stiffness in Patients with Diabetic Kidney Disease

Session Information

Category: Diabetic Kidney Disease

  • 602 Diabetic Kidney Disease: Clinical

Authors

  • Chiu, Liang-Te, Buddhist Tzu Chi General Hospital, Hualien, Select a state/province, Taiwan
  • Lin, Lin, Buddhist Tzu Chi General Hospital, Hualien, Select a state/province, Taiwan
  • Hsu, Bang-Gee, Buddhist Tzu Chi General Hospital, Hualien, Select a state/province, Taiwan
Background

Adiponectin plays an important role in cardiovascular disease through its anti-inflammatory and anti-atherogenic properties. The purpose of the present study was to examine the clinical variables and the relationship between serum adiponectin levels and aortic arterial stiffness in diabetic kidney disease (DKD).

Methods

Fasting blood samples were obtained from 80 patients with DKD. DKD is identified clinically by persistently high urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g and/or sustained reduction in estimated glomerular filtration rate (eGFR) below 60 ml/min per 1.73 m2. Carotid-femoral pulse wave velocity (cfPWV) was measured by using pressure applanation tonometry. cfPWV values of > 10 m/s represented the high aortic arterial stiffness group, while values ≤ 10 m/s defined the control group, according to the ESH-ESC 2013. Serum adiponectin level was measured using an enzyme immunoassay.

Results

In total, 41 patients with DKD (51.3%) were defined as high aortic stiffness group. Compared to the control group, high aortic stiffness group had high prevalence of male gender (P = 0.043), older age (P = 0.011), higher systolic blood pressure (P = 0.002) and UACR (P = 0.007), whereas serum adiponectin level (P = 0.001) were lower. After adjusting for confounders, serum adiponectin level (odds ratio (OR): 0.930, 95% confidence interval (CI): 0.884–0.978, P = 0.005), age (OR: 1.089, 95% CI: 1.028–1.154, P = 0.004), and systolic blood pressure (OR: 1.040, 95% CI: 1.013–1.068, P = 0.004) were independent predictors of aortic stiffness. Multivariable analysis showed that the serum adiponectin level (β = -0.309, adjusted R2 change = 0.087, P = 0.002) was negatively associated with cfPWV values in DKD patients. The area under the receiver-operating characteristic (ROC) curve predicting aortic stiffness by serum adiponectin level in DKD patients was 0.728 (95% CI: 0.617-0.822, P = 0.0001).

Conclusion

Among DKD patients, serum adiponectin level was inversely associated with cfPWV values and was independent predictor of aortic stiffness.