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Kidney Week

Abstract: TH-PO864

Multiple Urinary Tract Infections Are Associated with Genotype and Phenotype in Adult Polycystic Kidney Disease

Session Information

Category: Genetic Diseases of the Kidneys

  • 1001 Genetic Diseases of the Kidneys: Cystic

Author

  • Eroglu, Eray, Erciyes University School of Medicine, Kayseri, Turkey
Background

The association between UTI among genotypic and phonotypic properties of ADPKD patients is still obscure. Thus, we investigated the relationship between UTI and polycstin gene mutation with total kidney volume.

Methods

Ambulatory blood pressure monitoring was performed in all participants. Magnetic resonance imaging (MRI) was performed with a 1.5-T system, and total kidney volumes were calculated using mid-slice technique. To determine PKD1 and PKD2 genotype, we performed molecular and genetic tests involving the following steps: DNA isolation, next-generation sequencing (NGS) and data analysis.

Results

ADPKD patients with UTI had lower eGFR values than those without UTI [64.9(32.2-100.8) vs 89.5(59.0-110.0), (p:0.041)]. In addition, patients with UTI had significantly increased height adjusted total kidney volume than patients without UTI [950(290-1350) vs 345(243-780.0), (p:0.005)] (Figure-1). Multiple logistic regression analysis showed that the PKD1 truncating mutation and hTKV independently predicted UTI. The sensitivity and specificity of hTKV were 65% and 77% (cut-off >727cm3) with an area of under the ROC curve of 0.70 (95% CI: 0.56-0.85, p:005) (Figure-2).

Conclusion

ADPKD patients with larger kidneys and PKD1 mutation are susceptible to increased risk of multiple UTI. Additionally, renal function decreased in ADPKD patients with multiple UTI history.

Funding

  • Government Support - Non-U.S.