Abstract: TH-PO755
Is the Prognosis of a Single Functioning Kidney Benign? A Population-Based Study
Session Information
- Pediatric CKD
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1700 Pediatric Nephrology
Authors
- Alfandary, Hadas, schneider children''s medical center, Petah tikva, Israel
- Haskin, Orly, schneider children''s medical center, Petah tikva, Israel
- Borovitz, Yael, schneider children''s medical center, Petah tikva, Israel
- Levi, Shelly Shlomit, schneider children''s medical center, Petah tikva, Israel
- Dagan, Amit, schneider children''s medical center, Petah tikva, Israel
- Erlich, Tomer, sheba medical center, Tel Aviv, Israel
- Davidovits, Miriam, schneider children''s medical center, Petah tikva, Israel
- Pleniceanu, Oren, Pediatric stem cell research institute, Sheba medical center, Petach Tqiwa, Israel
Background
Solitary functioning kidney ( SFK) is an important condition in the spectrum of congenital anomalies of kidney and urinary tract ( CAKUT). The long term outcome of congenital SFK is underactive research. We conducted a large scale population based study to investigate an early renal injury in adolescents with SFK.
Methods
We accessed data from the compulsory medical evaluation of 17 years old in Israel, prior to their enlistment for military service during 2006-2018. The incidence of SFK and the incidence of renal injury defined as proteinuria, hypertension or decreased eGFR were documented.
Results
of 978997 candidates, 354 had diagnosis of SFK. The peak incidence was 1:1500 in 2012. Male to female ratio 2.7:1. 28.1% of the cohort were overweight ( BMI>25) Proteinuria was reported in 17% of the cohort. Systolic blood pressure above 120mmHg/ 130mmHg was documented in 53.8% and 28.1% respectively. Diastolic blood pressure above 80mmHg/ 85mmHg was documented in 12.8 and 9.1% respectively.
eGFR below 90ml/min/1.73m2 was reported in 12.1%. Concomitant genital malformations were documented in 5.5%.
Conclusion
this large population based study documents a significant risk for renal injury among adolescent with SFK at the age of 17 years old.