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Abstract: FR-PO276

Interaction Between Alcohol Intake and Diabetes in Relation to the Risk of ESRD in the Singapore Chinese Health Study

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Geng, Tingting, National University of Singapore, Singapore, Singapore
  • Jafar, Tazeen H., Duke-NUS Graduate Medical School, Singapore, Singapore
  • Yuan, Jian-Min, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Koh, Woon-Puay, Duke-NUS Medical School, Singapore, Singapore
Background

The relationship between alcohol intake and risk of end-stage renal disease (ESRD) is controversial. Moreover, whether the association is modified by diabetes status is unknown.

Methods

We examined the association between alcohol intake and risk of ESRD in the Singapore Chinese Health Study, a prospective population-based cohort of 63,257 adults aged 45-74 years at recruitment (1993-1998). Information on alcohol intake, diet, medical history and other lifestyle factors was collected at recruitment. We identified 1,217 ESRD cases via linkage with National Singapore Renal Registry through 2015. Cox proportional hazards regression method was used to estimate hazard ratios (HRs) and 95% confidence interval (CI) of ESRD in relation to alcohol intake by diabetes status over an average 17.5 years of follow-up.

Results

Among the participants without diabetes at baseline, monthly to weekly alcohol intake was associated with a decreased risk of ESRD (HR 0.69, 95 % CI 0.55-0.88) compared to the non-drinkers, whereas the reduced risk was no longer significant among the participants with diabetes (Pinteraction=0.21). Comparatively, alcohol intake with ≥2 drinks/day was significantly associated with an increased risk of ESRD compared to the abstainers among the diabetic patients (HR 2.12, 95% CI 1.19-3.78) but not associated with the risk among those without diabetes (Pinteraction=0.02). Presence of heavy alcohol drinking and diabetes was associated with a 12-fold increased risk of ESRD compared with the absence of both factors (HR 12.0, 95% CI 7.00-20.7).

Conclusion

In conclusion, low-dose alcohol intake may have potential renal protective effect among individuals without diabetes. However, alcohol intake with ≥2 drinks/day could act synergistically with diabetes in increasing ESRD risk.

Funding

  • Other NIH Support