Abstract: SA-PO210
Increased Risk of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients and Patients on Chronic Dialysis: A Cancer Registry-Based Study in Taiwan
Session Information
- Onco-Nephrology: Clinical
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Onco-Nephrology
- 1500 Onco-Nephrology
Author
- Sue, Yuh-Mou, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan
Background
Organ transplant recipients (OTRs), patients on chronic dialysis, and those with chronic kidney disease (CKD) have immune dysregulation and are at higher risk of skin cancers. However, the predominant histological skin cancer subtype in these populations has not been well-investigated among Asians. This study aimed to investigate the predominant histological skin cancer subtype among OTRs, patients on chronic dialysis, and those with CKD in Taiwan.
Methods
We obtained data between 2007 and 2014 from the Taiwan Cancer Registry Database and the National Health Insurance Research Database. The proportions of certain histological skin cancer subtypes in OTRs, patients on chronic dialysis, and those with CKD were compared against those in the control group using a generalized estimating equation regression model.
Results
Among 23,644 patients with skin cancer, 53 were OTRs, 255 had chronic dialysis, 1,792 had CKD, and 21,544 were placed in the control group. The proportions of squamous cell carcinoma (SCC) were 52.8%, 47.8%, 40.1%, and 33.5%, respectively. Compared with the control group, OTRs (1.99-fold) and chronic dialysis patients (1.25-fold) were found to have higher risk of developing SCC than other skin cancers after adjustment for potential confounding factors. Other subgroups or covariates associated with increased SCC risk included CKD patients aged < 70 years (vs. control group; 1.3-fold), old age (vs. young age; 2.8-fold), male sex (vs. female sex; 1.1-fold), and south-Taiwan residency (vs. north-Taiwan residency; 1.1-fold).
Conclusion
OTRs and patients on chronic dialysis had a greater risk of developing SCCs than other skin cancer subtypes.