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Abstract: TH-PO625

The Influence of an Elevated Serum Uric Acid Levels for Cardiovascular Events in the General Population with Normal Renal Function

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Matsuura, Yuki, Iwate medical university, Morioka, Iwate, Japan
  • Asahi, Koichi, Iwate Medical University, Morioka, Iwate, Japan
Background

The significance of an elevated serum uric acid (SUA) level as a risk factor for the onset of cardiovascular events (CVEs) remains controversial. Since the SUA level is affected by the impaired renal function, we evaluated the association between the SUA level and the incidence of CVEs in the Japanese general population without chronic kidney disease (CKD).

Methods

The baseline survey items were the SUA level, age, sex, body mass index (BMI),blood pressure, blood sugar, hemoglobin A1c, serum creatinine, estimated glomerular filtration rate, urinary albumin/creatinine ratio, total cholesterol, and electrocardiogram findings (existence of atrial fibrillation). Baseline data were measured in participants of annual health checkups from a community-based population. After the exclusion of CKD, the subjects were stratified into sex-specific quartiles of SUA (n = 15,036, mean age 63.2 ± 10.0 years in men and 60.6 ± 9.6 years in women, men 33.5%, including 5,038 men and 9,998 women). The endpoint was determined as the composite of CVEs (stroke, myocardial infarction, and sudden cardiac death). A Cox regression analysis was performed to examine the sex-specific relationship between the baseline SUA level and the onset of CVEs.

Results

During a mean follow-up period of 8.8 years, we confirmed 611 CVEs (304 in men, 307 in women). After adjusting for traditional risk factors (age, BMI, hypertension, diabetes mellitus, hypercholesterolemia, atrial fibrillation), the hazard ratio for the onset of CVEs did not differ among the quartiles in men (q1 (2.1≤SUA(mg/dl)≤4.8) = reference, q2 (4.9≤SUA(mg/dl)≤5.6) = 0.80, q3 (5.7≤SUA(mg/dl)≤6.4) = 1.01, q4 (6.5≤SUA(mg/dl)≤12.0) = 0.99; p = 0.447). In contrast, in women, a significant trend was observed (q1 (2.0≤SUA(mg/dl)≤3.7) = reference, q2 (3.8≤SUA(mg/dl)≤4.3) = 1.28, q3 (4.4≤SUA(mg/dl)≤4.9) = 1.58, q4 (5.0≤SUA(mg/dl)≤10.3) = 1.58; p = 0.035).

Conclusion

In the Japanese general population with normal renal function, an elevated SUA level is considered an independent risk factor for the onset of CVEs in women but not in men.