Comparing Glomerular Filtration Rate Equations with <sup>51</sup>Cr-EDTA in Patients with Renal Tumors
November 09, 2019 | 10:00 AM - 12:00 PM
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Comparing Glomerular Filtration Rate Equations with 51Cr-EDTA in Patients with Renal Tumors
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
- 1500 Onco-Nephrology
- Rodrigues, Gilberto José, ICESP - USP (Sao Paulo State Cancer Institute, University of Sao Paulo), São Paulo, Brazil
- Guglielmetti, Giuliano Betoni, São Paulo State Cancer Institute, São Paulo, Brazil
- Torres, Veronica, Sao Paulo State Cancer Institute - USP, Sao Paulo, Brazil
- Costalonga, Elerson, School of Medicine, University of Sao Paulo, São Paulo, SÃO PAULO, Brazil
- Cordeiro, Maurício, São Paulo Institute Cancer Center, São Paulo, Brazil
- Caires, Renato Antunes, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
- Nahas, William C., University of São Paulo Brazil, Sao Paulo, Brazil
Gilberto José Rodrigues,
Giuliano Betoni Guglielmetti,
Renato Antunes Caires,
William C. Nahas,
Assessment of glomerular filtration rate (GFR) is a crucial element to plan surgical strategies in patients with renal tumors. However, the estimate GFR (eGFR) trough equations was not validated in these patients. The aim of this study is to compare the performance of Chronic Kidney Disease Epidemiology Collaboration Equation (CKD-EPI), abbreviated Modification of Diet in Renal Disease (aMDRD) and Cockcroft-Gault (CG) equations with 51Cr-EDTA in patients with renal tumors eligible to surgical treatment.
Prospective evaluation of 142 outpatients with renal tumors and submitted to partial nephrectomy at Sao Paulo State Cancer Institute between April 2013 and November 2018. All patients were evaluated before surgery with 51Cr-EDTA (rGFR) and serum creatinine (SCr), standardized to the isotope-dilution mass spectrometry reference method. rGFR and eGFR were expressed as ml/min/1.73 m2.
Patients were 59.4 ± 10.6 y, 50.2% male, 97.9% white. Renal tumor has 3.50 (2.70-4.72) cm at largest diameter and was malignant (histology confirmed post surgery) in 85% of cases. Comparing renal function before surgery, SCr was 0.86 (0.74 – 1.10) mg/d, rGFR was 81.1 ± 22.5 and rGFR < 60 was observed in 18% of pts. eGFRs using the CKD-EPI, aMDRD and CG equations were 80.6 ± 20, 77.3 ± 20.8, and 89.2 ± 30.6, respectively. CG and aMDRD showed significant differences in the means from the paired t-Test when compared to rGFR (P<0.05) (Figure 1 - Table 1). CKD-EPI equation demonstrated satisfactory precision and higher accuracy (Figure 1 - Table 2).
CG and aMDRD equations performed poorly compared with rGFR in this group of patients with renal tumors. CKD-EPI equation demonstrated adequate performance and should be considered when deciding upon surgical strategies in the setting of renal tumors.