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Abstract: TH-PO524

Bone Assessment by High-Resolution Peripheral Quantitative Computed Tomography in Premenopausal Stone-Forming (SF) Women

Session Information

Category: Bone and Mineral Metabolism

  • 401 Bone and Mineral Metabolism: Basic

Authors

  • Esper, Priscila Ligeiro Gon?alves, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Melo, Thalita Lima, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Ormanji, Milene Subtil, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Caparbo, Valéria De falco, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
  • Takayama, Liliam, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
  • Pereira, Rosa M., Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
  • Heilberg, Ita Pfeferman, Universidade Federal de São Paulo, Sao Paulo, Brazil
Background

Nephrolithiasis has been associated to low bone mineral density (BMD). Bone assessment by Dual-energy X-ray absorptiometry (DXA) is widely used in clinical practice but has limitations as it only measures areal BMD (aBMD). New non-invasive technologies such as high-resolution peripheral quantitative computed tomography (HR-pQCT) provides additional information regarding bone quality and microarchitecture.

Methods

Forty-four (44) stone-forming (SF) premenopausal women (33.4±9.2 years old) and 202 age-matched healthy premenopausal women (33.7±9.0 years old) were included. aBMD was analyzed by DXA and volumetric BMD (vBMD), structure and biomechanical parameters of the distal radius and tibia were assessed by HR-pQCT.

Results

SF presented a trend for lower aBMD versus controls at L1-L4 (0.979±0.115 vs 1.013±0.111 p=0.06) and significant lower aBMD at femoral neck (0.787±0.11 vs 0.826±0.118 p=0.02) , total hip (0.896±0.116 vs 0.932±0.12 p =0.04) and distal radius (0.668±0.049 vs 0.686±0.047 p=0.03). As shown in Table 1, trabecular number (Tb.N) was significantly lower and trabelcular separation (Tb.Sp) was significantly higher in SF compared to controls at both sites. Trabecular vBMD at distal radius was also significantly lower in SF versus controls.

Conclusion

Premenopausal SF women presented lower areal BMD than controls. HR-pQCT further disclosed that the trabecular compartment possibly accounts for this finding, due to lower trabecular volumetric BMD at distal radius, lower trabecular number and increased trabecular separation at both distal radius and tibia. The underlying mechanism for these important alterations of bone quality in this population deserves further investigation.

Tt.vBMD: total vBMD; Tb.vBMD: trabecular vBMD; Ct.vBMD: cortical vBMD; Tb.N: trabecular number; Tb.Th: trabecular thickness; Tb.Sp: trabecular separation; Ct.Th: cortical thickness ; (#) Advanced cortical analyses (N=96 controls); SF vs Controls: (*) p<0.05 (**) p<0.001

Funding

  • Government Support - Non-U.S.