ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on Twitter

Kidney Week

Abstract: TH-PO201

Prevalence of Body Weight Variations in the Pre-Dialysis Period and the Effect of Hemodialysis Initiation: A Single-Centre Retrospective Observational Study

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis


  • Mohammed, Azharuddin, Armed Forces Hospital-Taif Region, Taif, Makkah, Saudi Arabia
  • Alazwari, Monther Nasser, Armed Forces Hospital-Taif Region, Taif, Makkah, Saudi Arabia

Body weight(BW) changes rapidly during pre-dialysis(pre-D) period and is regularly monitored during pre-D clinics but less utilised as an indication for RRT initiation in isolation. Hemodialysis(HD) provides a target weight (TW).
Aims:To 1) Assess prevalence and magnitude of BW changes during pre-D 2) Measure the effect of RRT initiation on BW 3 months(m) post HD


We retrospectively examined BW changes of a large cohort of incident HD patients who attended Pre-D clinics between 2012-2016 (n=103). Excluded:Those with missing BW between 2-5 m in pre-D and 2-5 m after RRT initiation, previous PD, HD or fluid overload as indication for RRT initiation (n= 38).
W0, W1and W2 are the corresponding BW at -3 m(Pre-D clinic), pre-weight at 1stHD initiation and post-HD TW after +3 m. Delta BW is calculated as absolute and % change for Pre-D(W0-W1) and HD period(W1-W2). Weight loss and Weight gain data analysed using Past.V3 software.


n= 65, mean age 68±12 yr, M:F 44:21. HD was RRT in all. Pre-D and HD intervals were similar 99 ± 29 Vs. 92 ± 13.6 days. Post-weight and TW were within 0.5±0.4 Kg.Weight loss seen in both pre-D and HD; it slowed modestly after HD initiation (66.4% to 56.9%) mainly in 0-5% (40% Vs. 26%) (Fig 1). Weight gain was mostly 0 - 9.9% on HD as compared to pre-D (38.4 Vs 27.7). High weight gainers of >10% BW reduced from 7.7% in the pre-D period to 4.6% on HD, probably reflecting closer monitoring of TW.
However, group comparison of pre-D and HD for % BW changes did not reach statistical significance for weight loss (difference between means 1.47, 95% CI -1.45 to 4.48, p=0.35) or weight gain (difference between means 0.12, 95% CI -2.86 to 3.11, p=0.93).


Uremic state is predominantly catabolic in both pre-D and HD period; RRT initiation can provide anabolic milieu. Increased recognition/incorporation of BW changes is needed as an added indication for RRT initiation. Body composition monitor use could well extend into pre-D clinics to guide bedside decisions.