Abstract: SA-PO214
Dipstick Proteinuria and Cancer Incidence: A Nationwide Population-Based Study
Session Information
- Onco-Nephrology: Clinical
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Onco-Nephrology
- 1500 Onco-Nephrology
Authors
- Ahn, Shin-Young, Korea University Medical Center, Korea University Guro Hospital, Seoul, Korea (the Republic of)
- Ko, Gang Jee, Korea University Medical Center, Korea University Guro Hospital, Seoul, Korea (the Republic of)
- Kwon, Young-Joo, Korea University Medical Center, Korea University Guro Hospital, Seoul, Korea (the Republic of)
Background
Proteinuria is a representative indicator of chronic kidney disease (CKD) and an independent risk factor for both cardiovascular and non-cardiovascular mortality. Given that a major cause of non-cardiovascular mortality is malignancy, the association between proteinuria and malignancy has been discussed for several decades. We evaluated the clinical implication of dipstick proteinuria as a predictor for malignancy using nationwide population-based data.
Methods
We included subjects who had undergone a medical examination in 2009 (index year). Among 10,505,818 participants, we excluded subjects who did not satisfy the inclusion criteria. Finally, 9,714,387 subjects were included in this study and were followed from the index year to December 31, 2017. We categorized the results of dipstick proteinuria into three groups; negative (-), trace (±), overt proteinuria (more than 1+).
Results
The participants with overt proteinuria were more likely to be older, have hypertension, diabetes, and dyslipidemia. During the follow up period, we observed that overt proteinuria at baseline correlated with the risk of overall cancer incidence, even after it was adjusted by age, gender, smoking history, degree of exercise and diabetes (HR 1.151, 95% CI, 1.133 – 1.169, referenced to no proteinuria). In terms of site-specific cancer, the risks of colorectal, liver, lung, cervical, esophagus, kidney, bladder, and prostate cancer incidence gradually increased in proportion to the degree of proteinuria. In order to observe the risk of cancer incidence according to the change in proteinuria, we used the same participant’s records from the 2005 NHID (National Health Insurance Database). We demonstrated that the risk of cancer incidence increased proportionally according to the changes in dipstick proteinuria over four years.
Conclusion
We elucidated the dose-response relationship between the degrees of dipstick proteinuria and the graded risk of overall and site-specific cancer development. We also observed that the long-term risk of cancer incidence increased proportionally according to the changes in dipstick proteinuria over four years.